Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-01-25
2011-01-25
Aulakh, Charanjit S (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S278000, C435S184000
Reexamination Certificate
active
07875628
ABSTRACT:
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
REFERENCES:
patent: 6238876 (2001-05-01), Altaba
patent: 6291516 (2001-09-01), Dudek et al.
patent: 6432970 (2002-08-01), Beachy et al.
patent: 6867216 (2005-03-01), Beachy et al.
patent: 7098196 (2006-08-01), Beachy et al.
patent: 7230004 (2007-06-01), Adams et al.
patent: 7291626 (2007-11-01), Beachy et al.
patent: 7407967 (2008-08-01), Adams et al.
patent: 2003/0114393 (2003-06-01), Liscovitch et al.
patent: 2004/0072913 (2004-04-01), Tas et al.
patent: 2004/0072914 (2004-04-01), Tas et al.
patent: 2004/0110663 (2004-06-01), Dudek et al.
patent: 2004/0126359 (2004-07-01), Lamb et al.
patent: 2004/0127474 (2004-07-01), Dudek et al.
patent: 2006/0094660 (2006-05-01), Thomson
patent: 2006/0128639 (2006-06-01), Beachy
patent: 2006/0142245 (2006-06-01), Beachy et al.
patent: 2007/0009530 (2007-01-01), Altaba
patent: 2007/0231828 (2007-10-01), Beachy et al.
patent: 2007/0281040 (2007-12-01), Weichselbaum et al.
patent: 2008/0019961 (2008-01-01), Wicha et al.
patent: 2008/0057071 (2008-03-01), Watkins et al.
patent: 2008/0058298 (2008-03-01), Beachy et al.
patent: 2008/0095761 (2008-04-01), Beachy et al.
patent: 2008/0118493 (2008-05-01), Beachy et al.
patent: WO-95/18856 (1995-07-01), None
patent: WO-96/17924 (1996-06-01), None
patent: WO-00/41545 (2000-07-01), None
patent: WO-01/27135 (2001-04-01), None
patent: WO-01/49279 (2001-07-01), None
patent: WO-02/30462 (2002-04-01), None
patent: WO-2005/013800 (2005-02-01), None
patent: WO-2005/032343 (2005-04-01), None
patent: WO-2005/042700 (2005-05-01), None
patent: WO-2006/026430 (2006-03-01), None
patent: WO-2007/123511 (2007-11-01), None
patent: WO-2008/083248 (2008-07-01), None
patent: WO-2008/083252 (2008-07-01), None
patent: WO-2008/089123 (2008-07-01), None
Alexandre et al., Genes Dev. (1996) 10:2003-2013.
Belloni et al., Nature Genetics (1996) 14:353-356.
Berman et al., Nature (2003) 425:846-851.
Chen et al., Genes and Development (2002) 16:2743-2748.
Cooper et al., Science (1998) 280:1603-1607.
Fan et al., Endocrinology (2004) 145:3961-3970.
Karhadkar et al., Nature (2004) 431:707-712.
Kitajima et al., Heterocycles (1981) 15:791-796.
Kubo et al., Cancer Research (2004) 64:6071-6074.
Lee et al., Journal of Agricultural and Food Chemistry (2003) 51(3):582-586.
Lewis et al., Journal of Mammary Gland Biology and Neoplasia (2004) 2:165-181.
Quirk et al., Cold Spring Harbor Symp. Quant. Biol. (1997) 62:217-226.
Reifenberger et al., Cancer Res. (1998) 58:1798-1803.
Sheng et al., Molecular Cancer (2004) 3:29-42.
Supplementary Partial European Search Report for EP 05791140.6, mailed Nov. 26, 2007, 7 pages.
Tas et al., Dermatology (2004) 209:126-131.
Thayer et al., Nature (2003) 425:851-856.
Watkins et al., Nature (2003) 422:313-317.
Xie et al., Nature (1998) 391:90-92.
International Search Report for PCT/US05/30406, mailed on Apr. 4, 2006, 2 pages.
Bale and Yu, Human Molecular Genetics (2001) 10:757-762.
Berge et al, Journal of Pharmaceutical Sciences (1977) 66:1-19.
Berman et al., Science (2002) 297:1559-1561.
Ma et al., Carcinogenesis (2005) 10:1698-1705.
Nakamura et al., Biochemical and Biophysical Research Communications (1997) 237:465-469.
Patil et al., Cancer Biology & Therapy (2006) 5:111-117.
Peacock et al., PNAS USA (2007) 104:4048-4053.
Pietsch et al, Cancer Research (1997) 57:2085-2088.
Rahman et al., Phytochemistry (1991) 1:368-370.
Sicklick et al, Carcinogenesis (2006) 27:748-757.
Van Der Horst et al., Bone (2003) 33:899-910.
Williams et al., PNAS USA (2003) 100:4616-4621.
Bar, Elis E. et al., “Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Gliobastoma”, Stem Cells, vol. 25, pp. 2524-2533, (2007).
Feldmann, Georg et al., “Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers”, Cancer Research, vol. 67, No. 5, pp. 2187-2196, (2007).
Pasca di Magliano, Marina et al., “Hedgehog Signalling in Cancer Formation and Maintenance”, Nature Reviews/Cancer, vol. 3, pp. 903-911, (2003).
Sims-Mourtada, Jennifer et al., “Hedgehog: an Attribute to Tumor Regrowth after Chemoradiotherapy and a Target to Improve Radiation Response”, Clinical Cancer Research, vol. 12, No. 21, pp. 6565-6572, (2006).
Rubin, Lee L. et al., “Targeting the Hedgehog Pathway in Cancer”, Nature Reviews/Drug Discovery, vol. 5, pp. 1026-1033, (2006).
Taipale, Jussi et al., “Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine”, Nature, vol. 406, pp. 1005-1009, (2000).
Tremblay, Martin R., “Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists”, Journal of Medicinal Chemistry, vol. 51, pp. 6646-6649, (2008).
(Exhibit 1) Bhattacharya, Resham et al., “Role of Hedgehog Signaling in Ovarian Cancer”, Clin. Cancer Research, vol. 14, No. 23, (2008), pp. 7659-7666.
(Exhibit 2) Dormeyer, Wilma et al., “Plasma Membrane Proteomics of Human Embryonic Stem Cells and Human Embryonal Carcinoma Cells”, Journal of Proteome Research, vol. 7, No. 7, (2008), pp. 2936-2951.
Adams Julian
Castro Alfredo C.
Foley Michael A.
Janardanannair Somarajannair
Nevalainen Marta
Aulakh Charanjit S
Fish & Richardson P.C.
Infinity Discovery, Inc.
LandOfFree
Cyclopamine analogues and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclopamine analogues and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclopamine analogues and methods of use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2742608