Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-08-08
2006-08-08
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S247000
Reexamination Certificate
active
07087630
ABSTRACT:
The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.
REFERENCES:
patent: 5474995 (1995-12-01), Ducharme et al.
patent: 5536752 (1996-07-01), Ducharme et al.
patent: 5550142 (1996-08-01), Ducharme et al.
patent: 5633272 (1997-05-01), Talley et al.
patent: 5710140 (1998-01-01), Ducharme et al.
patent: 5719163 (1998-02-01), Norman et al.
patent: 5859257 (1999-01-01), Talley
patent: 5945539 (1999-08-01), Haruta et al.
patent: 5985902 (1999-11-01), Talley et al.
patent: 5994381 (1999-11-01), Haruta et al.
patent: 6002014 (1999-12-01), Haruta et al.
patent: 6040341 (2000-03-01), Del Soldato et al.
patent: 6297260 (2001-10-01), Bandarage et al.
patent: 6362209 (2002-03-01), Haruta et al.
patent: 6436967 (2002-08-01), Talley et al.
patent: 6482956 (2002-11-01), Luengo et al.
patent: 6673818 (2004-01-01), Brown et al.
patent: 6699884 (2004-03-01), Brown et al.
patent: 2004/0006133 (2004-01-01), Ranatunge et al.
patent: 2004/0072883 (2004-04-01), Garvey et al.
patent: 2004/0082652 (2004-04-01), Del Soldato et al.
patent: 2005/0032851 (2005-02-01), Talley et al.
patent: 2005/0032852 (2005-02-01), Carter
patent: 2005/0101661 (2005-05-01), Del Soldato et al.
patent: WO 95/15316 (1995-06-01), None
patent: WO 95/18799 (1995-07-01), None
patent: WO 96/25405 (1996-08-01), None
patent: WO 96/36617 (1996-11-01), None
patent: WO 97/38986 (1997-10-01), None
patent: WO 00/25776 (2000-05-01), None
patent: WO 01/45703 (2001-06-01), None
patent: WO 04/000300 (2003-12-01), None
patent: WO 04/000781 (2003-12-01), None
patent: WO 04/024186 (2004-03-01), None
patent: WO 05/030224 (2005-04-01), None
Jun. 9, 2004. International Search Report from PCT/US03/19850.
Jul. 11, 2005. Supplementary European Search Report for European Patent Application No. 03762000.2.
Bandarage Upul K.
Earl Richard A.
Ezawa Maiko
Fang Xinqin
Garvey David S.
Nitromed Inc.
Stockton Laura L.
Wilmer Cutler Pickering Hale and Dorr LLP
LandOfFree
Cyclooxygenase 2 selective inhibitors, compositions and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclooxygenase 2 selective inhibitors, compositions and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclooxygenase 2 selective inhibitors, compositions and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3617890