Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

10494221

ABSTRACT:
The invention relates to a combination which comprises (a) a cyclooxygenase-2 inhibitor (“COX-2 inhibitor”) and (b) a histone deacetylase inhibitor (“HDAI”) for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of pre-malignant colon lesions or a colon cancer or other malignancies in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating pre-malignant colon lesions (e.g. polyps) and colon cancer, as well as other malignancies, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.

REFERENCES:
patent: 6291523 (2001-09-01), Fujimoto et al.
patent: 6552065 (2003-04-01), Remiszewski et al.
Salih A.K. et al., “Breast cancer prevention: present and future,” Cancer Treatment Reviews, vol. 27, pp. 261-273 (2001).
Fabian C. J. et al., “Beyond tamoxifen: New endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention,” Annals of the New York Academy of Sciences, vol. 952, pp. 44-59 (2001).

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