Cyclooctapeptides

Details Cyclooctapeptides Cyclooctapeptides

1980-12-15

1982-11-09

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125S, A61K 3700, C07C10352

Patent

active

043584390

ABSTRACT:
Cyclic peptides of the formula ##STR1## in which trp represents L-Trp, D-Trp, or an analogous radical which carries a halogen atom in the indole nucleus, Ac.sub.A represents hydrogen, or an acyl radical Ac of a carboxylic acid present at the .epsilon.-amino group, A represents L-Phe, D-Phe, L-Phg or D-Phg, or a corresponding radical having a substituted or saturated phenyl ring, and B represents the residue of a .gamma.- or .delta.-amino-lower alkanecarboxylic acid which may carry an optionally substituted cyclic hydrocarbyl radical Ar, and also pharmacologically tolerable salts and therapeutically acceptable complexes thereof can be used as an antidiabetic in an analogous manner to somatostatin. They can be obtained by conventional processes of peptide chemistry, especially by cyclisation of corresponding linear peptides.

REFERENCES:
patent: 3725380 (1973-04-01), Konig et al.
patent: 3862113 (1975-01-01), Riniker et al.
patent: 3872074 (1975-03-01), Konig et al.
patent: 3875207 (1975-04-01), Iselin et al.
patent: 3944590 (1976-03-01), Iselin et al.
patent: 4146612 (1979-03-01), Veber
patent: 4238481 (1980-12-01), Rink et al.
Science 179, 77 (1973).

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