Cyclooctanone derivatives and cyclodecanone derivative, and...

Details Cyclooctanone derivatives and cyclodecanone derivative, and... Cyclooctanone derivatives and cyclodecanone derivative, and...

2005-09-27

2005-09-27

Zucker, Paul A. (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S544000, C514S683000, C560S020000, C560S073000, C560S106000, C568S329000

Reexamination Certificate

active

06949585

ABSTRACT:
The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic group which may be substituted; the partial structure -DE- represents a group represented by —CH2CH2— or —CH═CH—; W represents a group represented by —CH2—, —CH2CH2—, —CH═CH— or —CH═; the partial structure >XY— represents a group represented by >CH—(CH2)n—, >C═CH—, >CH—CH2—CH(OH)—, >CH—CH2—C(═O)—, >CH—O— or >CH—O—CO—, provided that when W is —CH═, then XY— represents C—(CH2)p—; Z represents a divalent aliphatic hydrocarbon group; R1and R2, which may be the same or different, each represents a hydrogen atom, or a hydroxyl, alkoxy or alkoxyalkoxy group; m is an integer of 0 or 1].

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Peter Jones et al.,Zeitschrift fur Kristallographie,1983, 163:75-84.
Bruce Beutler et al.,Nature,1986, 320(17):584-588.
Tadamitsu Kishimoto,J. of Amer. Soc. of Hermatology,1989, 74(1):1-10.

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