Cyclohexylphenyl carboxamides tocolytic oxytocin receptor...

Details Cyclohexylphenyl carboxamides tocolytic oxytocin receptor... Cyclohexylphenyl carboxamides tocolytic oxytocin receptor...

2007-04-10

2007-04-10

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S561000

Reexamination Certificate

active

10119994

ABSTRACT:
The present invention provides novel tricyclic benzodiazepine carboxamides compounds and methods and pharmaceutical compositions utilizing them for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression suppression of preterm labor, suppression of labor at term prior to caesarean delivery, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

REFERENCES:
patent: 4766108 (1988-08-01), Ali
patent: 5055448 (1991-10-01), Manning et al.
patent: 5070187 (1991-12-01), Gavras et al.
patent: 5258510 (1993-11-01), Ogawa et al.
patent: 5436333 (1995-07-01), Venkatesan et al.
patent: 5459131 (1995-10-01), Albright et al.
patent: 5466584 (1995-11-01), Tanizawa et al.
patent: 5512563 (1996-04-01), Albright et al.
patent: 5516774 (1996-05-01), Albright et al.
patent: 5521173 (1996-05-01), Venkatesan et al.
patent: 5532235 (1996-07-01), Albright et al.
patent: 5536718 (1996-07-01), Albright et al.
patent: 5609851 (1997-03-01), Bennani
patent: 5654297 (1997-08-01), Albright et al.
patent: 5665719 (1997-09-01), Bock et al.
patent: 5670509 (1997-09-01), Evans et al.
patent: 5726172 (1998-03-01), Sparks et al.
patent: 5736540 (1998-04-01), Albright et al.
patent: 5753644 (1998-05-01), Ogawa et al.
patent: 5756497 (1998-05-01), Bell et al.
patent: 5756504 (1998-05-01), Bock et al.
patent: 5780471 (1998-07-01), Venkatesan et al.
patent: 5849735 (1998-12-01), Albright et al.
patent: 5880122 (1999-03-01), Trybulski et al.
patent: 5968930 (1999-10-01), Albright et al.
patent: 6268359 (2001-07-01), Ogawa et al.
patent: 6340678 (2002-01-01), Matushisa et al.
patent: 2002/0183311 (2002-12-01), Failli et al.
patent: 2002/0198196 (2002-12-01), Failli et al.
patent: 2003/0004159 (2003-01-01), Failli et al.
patent: 2003/0008863 (2003-01-01), Failli et al.
patent: 2003/0018026 (2003-01-01), Failli et al.
patent: 2003/0055046 (2003-03-01), Failli et al.
patent: 2003/0055047 (2003-03-01), Failli et al.
patent: 0 382 185 (1990-08-01), None
patent: 0 470 514 (1992-02-01), None
patent: 0 514 667 (1992-11-01), None
patent: 0 533 240 (1993-03-01), None
patent: 0 533 242 (1993-03-01), None
patent: 0 533 243 (1993-03-01), None
patent: 0 533 244 (1993-03-01), None
patent: 0 620 216 (1994-10-01), None
patent: 0 636 625 (1999-01-01), None
patent: 2 326 410 (1998-12-01), None
patent: 2 326 639 (1998-12-01), None
patent: WO 91/05549 (1991-05-01), None
patent: WO 94/01113 (1994-01-01), None
patent: WO 94/04525 (1994-03-01), None
patent: WO 94/12476 (1994-06-01), None
patent: WO 94/14796 (1994-07-01), None
patent: WO 94/20473 (1994-09-01), None
patent: WO 96/09824 (1996-04-01), None
patent: WO 96/22282 (1996-07-01), None
patent: WO 96/22292 (1996-07-01), None
patent: WO 96/22294 (1996-07-01), None
patent: WO 96/22775 (1996-08-01), None
patent: WO 97/25992 (1997-07-01), None
patent: 98/20011 (1998-05-01), None
patent: 99/06409 (1999-02-01), None
patent: WO 99/24051 (1999-05-01), None
Zingg et al., The Oxytocin Receptor, TRENDS in Endocrinology and Metabolism, vol. 14, No. 5, pp. 222-227, Jul. 2003.
Mats Akerlund, Acta Obstet. Gynecol. Scand., 1987, 459-461, 66.
Mats Akerlund, Reg. Pept., 1993, 187-191, 45.
Ian M. Bell et al., J. Med. Chem., 1998, 2146-2163, 41.
Ya Li Chen et al., Eur. J. Pharmacol., 1999, 25-51, 376.
J.J. Evans et al., J. Endocrinol., 1989, 107-116, 122.
Ben E. Evans et al., J. Med. Chem., 1993, 3993-4006, 36.
Ben E. Evans et al., J. Med. Chem., 1992, 3919-3927, 35.
Anna-Riitta Fuchs et al., Science, 1982, 1396-1398, 215.
Andre Giroux et al., Tetr. Lett., 1997, 3841-3844, 38.
T. Murphy Goodwin et al., Obstet. Gynecol., 1996, 331-336, 88.
Aleksandar Jovanovic et al., Br. J. Pharmacol., 1997, 1468-1474, 12.
Mario Maggi et al., J. Clin. Endocrinol. Metab., 1990, 1142-1154, 70.
A. Okano, J. Reprod. Dev., 1996, 67-70, 42 (Suppl.).
D.J. Pettibone et al., Biochem. Soc. Trans., 1997, 1051-1057, 25(3).
V. Rettori et al., Proc. Nat. Acad. Sci. U.S.A., 1997, 2741-2744, 94.
G. Robinson et al., J. Endocrinol., 1990, 425-432, 125.
Olga Wellnitz et al., J. Dairy Res., 1999, 1-8, 66.
Gabor L. Kovacs et al., Psychoneuroendocrinology, 1998, 945-962, 23(8).
Margaret M. McCarthy et al., Molecular Medicine Today, 1997, 269-275, 3(6).
James. F. Leckman et al., Psychoeuroendocrinology, 1994, 723-749, 19(8).
Banker, G. S. et al., “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, p. 596.
PubMed Abstract 12848639, also cited as Acta Obstet Gynecol, 2003, 82(8), 687-704.
PubMed Abstract 12436949, also cited as Prog Brain Res, 2002, 139, 359-65.
PubMed Abstract 9891619, also cited as Clin Perinatol, 1998, 25(4), 859-71.
Wolff, Manfred E., “Burger's Medicinal Chemistry, 5ed, Part 1”, John Wiley & Sons, 1995, pp. 975-977.

Affiliated with

Also associated with

Rating

Cyclohexylphenyl carboxamides tocolytic oxytocin receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclohexylphenyl carboxamides tocolytic oxytocin receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclohexylphenyl carboxamides tocolytic oxytocin receptor... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3793319