Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2005-05-10
2005-05-10
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C564S085000
Reexamination Certificate
active
06890956
ABSTRACT:
Compounds of formula I:inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
REFERENCES:
patent: 2802013 (1957-08-01), Dodson
patent: 2812330 (1957-11-01), Dodson
patent: 0863134 (1998-09-01), None
patent: WO 0050391 (2000-08-01), None
patent: WO 03055850 (2003-07-01), None
patent: WO 03059335 (2003-07-01), None
L. Capuano, et al., “Cyclische S-Oxide”, Chemische Berichte, vol. 112, pp. 1012-1022 (1979).
J.M. Decesare, et al.:, “Gamma-and Beta-epoxy sulfones. Formation of different ring-sized products upon reaction with CH3MgI or LiN[CH(CH3)2]2”, Canadian Journal of Chemistry., vol. 59, pp. 1415-1424 (1981).
O. Eisleb, “Neue Synthesen mittels Natriumamids”, Berichte Der Deutschen Chemischen Gesellschaft, vol. 74, pp. 1433-1450 (1978).
J. Golinski, et al., “Reactions of Organic Anions; XVIV. Catalytic Two-Phase Alkylation of Benzyl Sulfones and Sulfonamides”, SYNTHESIS, No. 6, pp. 461-463 (1979).
P. Kisanga, et al., “Development, Synthetic Scope, and Mechanistic Studies of the Palladium-Catalyzed Cycloisomerization of Functionalized 1,6-Dienes in the Presence of Silane”, Journal of the American Chemical Society, vol. 122, No. 41, pp. 10017-10026 (2000).
C. Koradin, et al., “Cesium Catalyzed Addition of Nitriles to Alkynes”, SYNLETT, No. 10, pp. 1452-1454 (2000).
T. Oyuyama, et al., “Flash Photolytic Generation of a Dithio Carbocation from 1,3-Dithiolance Derivatives and Its Reaction with Nucleophiles”, Bulletin of the Chemical Society of Japan, vol. 64, No. 9, pp. 2751-2756 (1991).
M. Makosza, et al., “Ambiphilic Reactivity of 2,4-Dinitrobenzylp-Tolyl Sulfone Carbanion”, Polish Journal of Chemistry, vol. 72, pp. 1198-1201 (1998).
R. K. Norris, et al., “The Stereochemistry of the SRNl Reaction In Some Cyclohexane Derivatives”, TETRAHEDRON, Vol. 38, No. 8, pp. 1051-1057 (1982).
Churcher Ian
Harrison Timothy
Kerrad Sonia
Nadin Alan John
Owens Andrew Pate
Buchan Gavin M.
Merck Sharp & Dohme Limited
Solola Taofiq
Todaro John C.
Winokur Melvin
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