Cyclohexyl prostaglandin analogs as EP 4 -receptor agonists

Details Cyclohexyl prostaglandin analogs as EP 4 -receptor agonists Cyclohexyl prostaglandin analogs as EP 4 -receptor agonists

2004-08-16

2008-09-30

Shiao, Rei-tsang (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S529000, C549S008000, C560S129000

Reexamination Certificate

active

07429615

ABSTRACT:
The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP4agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following formula I:wherein the wavy segments represent α or β bond, dashed line represents the presence or absence of a bond W, Y, Z, R, R1, R2and R3are as defined in the specification.

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Bernady et al., 1977, CAS:87:22543.
Lopez-Pelegrin et al., 2000, CAS: 134:71397.
Ohuchida et al. , 1984, CAS: 100: 209457.
Floyd et al., 1979, CAS: 90:54519.

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