Cyclohexyl derivatives and their use as therapeutic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S253030, C514S227800, C514S235500, C514S318000, C514S357000, C540S597000, C544S060000, C544S124000, C544S360000, C546S194000, C546S335000

Reexamination Certificate

active

06953792

ABSTRACT:
The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21aand R21bare as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

REFERENCES:
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patent: 5519034 (1996-05-01), Kozlik et al.
patent: 5849795 (1998-12-01), Arcamone et al.
patent: 59/116243 (1984-07-01), None
patent: WO 00/25770 (2000-05-01), None
Chemical Abstracts, vol. 84, No. 23, Jun. 7, 1976, abstract No. 164575. Markaryan. E. A. et al. Arm. Khim. zh. (1975), 28(10), 829-35.
Steventon et al:Journal of Medicinal Chemistry, vol. 41, No. 23, 1998, pp. 4623-4635.
Database Chemcats AsInEx Compound Collection. May 10, 2001. Database accession No. 2002:174244 XP002172980.

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