Cyclohexyl derivatives

Details Cyclohexyl derivatives Cyclohexyl derivatives

2008-06-10

2009-06-09

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S252020, C514S252110, C514S253120, C514S254030, C514S254050, C514S255010, C544S121000, C544S238000, C544S357000, C544S360000, C544S367000, C544S369000, C544S372000, C544S391000

Reexamination Certificate

active

07544683

ABSTRACT:
The present invention relates to compounds of formula Iwherein R1and R2are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

REFERENCES:
patent: 2007/0167436 (2007-07-01), Nettekoven et al.
patent: 2007/0173511 (2007-07-01), Nettekoven et al.
patent: WO 2004/101546 (2004-11-01), None
patent: WO 2006/101808 (2006-09-01), None
Masaki et al.,Neuronal Histamine Regulates Food Intake, Adiposity, and Upcoupling Protein Expression in Agouti Yellow(Aγ/a)Obese Mice, Endocrinology, 144, pp. 2741-2748 (2003).
Hancock et al.,Antiobesity Effects of A-331440, A Novel Non-Imidazole Histamine H3Receptor Antagonist, European Journal of Pharmacology, 487, pp. 183-197 (2004).
Timmerman, H.,Histamine H3Ligands: Just Pharmacological Tools or Potential therapeutic Agents?, J. Med. Chem., 33, pp. 4-11 (1990).

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