Cyclohexyl and phenyl substituted enkephalins

Details Cyclohexyl and phenyl substituted enkephalins Cyclohexyl and phenyl substituted enkephalins

1981-12-14

1983-10-04

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

044077467

ABSTRACT:
The invention discloses cyclohexyl and phenyl substituted enkephalin derivatives of the formula: ##STR1## Where R.sub.1, R.sub.2, R.sub.4, and R.sub.8 is hydrogen or alkyl of R.sub.3 is alkylthioalkyl or alkylsulfinylalkyl, X is: ##STR2## R.sub.5 is cyclohexylmethyl, phenylmethyl, optionally substituted by --NO.sub.2, R.sub.6 is cyclohexyl or phenyl optionally substituted by R.sub.7 and R.sub.7 is hydrogen, an alkyl ester of carboxylic acid or hydroxyalkyl and the pharmaceutically acceptable salts, which are useful as analgesic agents.

REFERENCES:
patent: 4261883 (1981-04-01), Smolarsky
patent: 4309343 (1982-01-01), Gesellchen
patent: 4331593 (1982-05-01), Smithwick, Jr. et al.
patent: 4350627 (1982-09-01), de Castiglioni et al.
Biological Abstracts (1980), vol. 69, p. 12570.

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