Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-01-23
2007-01-23
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
10031764
ABSTRACT:
A cyclohexapeptide compound of general formula (I), wherein R1is C1–C20alkyl; C9–C20alkenyl; C9–C20alkoxyphenyl; an aryl group selected from: phenyl, biphenyl, terphenyl and naphthyl; C1–C12alkylphenyl, C2–C12alkenylphenyl, C1–C12alkoxyphenyl; linoleoyl; palmitoyl; 12-methylmyristoyl; 10,12-dimethylmyristoyl; or —COC6H4(p)OC8H17, R1and R3are independently —OH; —CN; —CH2NH2; —N3; aryl; substituted aryl; heterocyclyl and substituted heterocyclic with 1–3 of the same or different heteroatoms; aminoalkylamino; mono or di-substituted linear or cyclic aminoalkylamino; —OR, wherein, R is C1–C12alkyl; substituted alkyl of the type —(CH2)n—X, where n is 1–5 and X is Cl, Br, I, COOY, CN, NH2or a heterocyclic and where Y is C1–C6linear or branched alkyl; C2–C12-alkenyl; aryl; fused aryl; substituted aryl; a heterocyclic containing 1–3 heteroatoms; mono or di-substituted aminoalkyl; or a hydroxy protecting group; and R3may additionally be imidazolyl; R2and R4are independently —H or —OH; R5is —H or —CH3, R6is —H, —CH3or —CH2CONH2. R7is —H, —CH3or —OH. R8and R9are independently —H or —CH2-Sec.amine in which the sec.amine is attached to —CH2through its N linkage; and its pharmaceutically acceptable salts. The compounds are useful as antifungal agents.
REFERENCES:
patent: 5378804 (1995-01-01), Balkovec et al.
patent: 5541160 (1996-07-01), Balkovec et al.
patent: 5914313 (1999-06-01), Bouffard
patent: 9421677 (1994-09-01), None
patent: 9527074 (1995-10-01), None
patent: 9611210 (1996-04-01), None
patent: 9622784 (1996-08-01), None
“Synthesis . . . Pneumonia”, Journal of Medicinal Chemistry, US, American Chemical Society, Washington, vol. 35, No. 1, Jan. 10, 1992, pp. 194-198.
“Mulundocandin . . . Antibiotic”, Journal of Antibiotics, vol. XL, No. 8, Mar. 1987, pp. 275-280.
Gangopadhyay Ashok K.
Gund Vitthal G.
Lal Bansi
Audet Maury
Aventis Pharma Deutschland GmbH
Gupta Balaram
LandOfFree
Cyclohexapeptide compounds, processes for their production... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclohexapeptide compounds, processes for their production..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclohexapeptide compounds, processes for their production... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3740397