Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1990-03-12
1994-05-10
Cashion, Jr., Merrell C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
514 9, A61K 3702, C07K 706, C07K 512
Patent
active
053108736
ABSTRACT:
A cyclohexapeptide base which is the nucleus of closely related antibiotics obtained by culturing Zalerion arboricola and its salts are described. They are useful intermediates for the preparation of new semisynthetic compounds having antimicrobial activity.
REFERENCES:
patent: 4287120 (1981-09-01), Abbott et al.
patent: 4931352 (1990-06-01), Fromtling et al.
Schmatz, et al., "Treatment of Pneumocystis cannii pneumonia with 1,3,B-glucan synthesis inhibitors", 87, Proc. Natl. Acad. Sci. USA, pp. 5950-5943, 1990.
Schmatz Dennis M.
Schwartz Robert E.
Tkacz Jan S.
Turner Mervyn
Billups Richard C.
Cashion Jr. Merrell C.
DiPrima Joseph F.
Marshall S. G.
Merck & Co. , Inc.
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