Cyclohexanone extraction of 3-hydroxymethylcephalosporins

Details Cyclohexanone extraction of 3-hydroxymethylcephalosporins Cyclohexanone extraction of 3-hydroxymethylcephalosporins

1997-07-18

1998-09-01

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50128

Patent

active

058012419

ABSTRACT:
The cephalosporin intermediates, desacetyl 7-glutaryl ACA and desacetyl cephalosporin D, are obtained in the form of a concentrated aqueous solution from an aqueous solution containing said intermediates in less concentrated form by solvent extraction using cyclohexanone followed by back-extraction into water. The concentrated aqueous solution of intermediate is in a form which can be used for economical production of 7-ACA using known procedures.

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M.E. Wildfeuer, "Aqueous Acetylation of Desacetyl Glutaryl 7-Amino-Cephalosporanic Acid (7 ACA) and Speculation on the Origin of Cephalosporin C in Fermentation Broth," Journal of Antibiotics, 47(1), pp. 64-71, 1994.

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