Cyclohexanediol derivatives

Details Cyclohexanediol derivatives Cyclohexanediol derivatives

1998-05-15

1999-10-19

Lee, Howard C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

514738, 568828, 568833, 568834, A61K 31045, C07C 3514

Patent

active

059691905

ABSTRACT:
The compound, (E)-(1R,3R)-5-[(R)-11-hydroxy-7,11-dimethyl-dodec-2-enylidene]-cyclohexane -1,3-diol of the formula I: ##STR1## is useful in the treatment or prevention of hyperproliferative skin diseases, particularly psoriasis, basal cell carcinomas, disorders of keratinization and keratosis; or for reversing the conditions associated with photodamage.

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Zhao, et al., "New Discoveries in Vitamin D Related Compounds", Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida (USA), pp. 87-88 (1994).
Kutner, et al, "Synthesis of Retiferol RAD.sub.1 and RAD.sub.2, the Lead Representatives of a New Class of des-CD Analogs of Cholecalciferol", Bioorganic Chemistry, vol. 23, pp. 22-32 (1995).
Gilchrest, Retinoids and photodamage, British Journal of Dermatology, vol. 127, Suppl. 41, pp. 14-20, (1992).
Sicinski, et al., Synthesis and Biological Activity of 1.alpha.,25-Dihydroxy-18-norvitamin D.sub.3 and 1.alpha.,25-Dihydroxy-18, 19-dinorvitamin D.sub.3, J Med. Chem. vol. 39, pp. 4497-4506 (1996).

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