Cyclohexane derivatives and their use as therapeutic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S227500, C514S239500, C514S252140, C514S253010, C514S254100, C514S255020, C514S255030, C514S278000, C514S307000, C514S316000, C514S327000, C514S331000, C514S249000, C514S413000, C514S429000, C514S616000, C540S610000, C544S059000, C544S166000, C544S295000, C544S350000, C544S360000, C544S366000, C544S369000, C544S374000, C544S384000, C544S400000, C546S016000, C546S019000, C546S146000, C546S190000, C546S221000, C546S234000, C548S453000, C548S578000, C564S155000

Reexamination Certificate

active

07105507

ABSTRACT:
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R17, R21aand R21bare as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

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Ohnmacht et al. Annual Reports in Medicinal Chemistry, vol.33, p. 71-80 (1998).
Chemical Abstracts, vol. 123, No. 15, Oct. 9, 1995 Columbus, Ohio, US; abstract No. 198390, Abdel-Kreem, M.F.M. et al: & Database Chemabs X)002172915 & Bull. Pharm. Sci., Asiut Univ. (1994). vol. date 1994, 17(2), 105-12.
Ghazal, Abdel Rahim et al.:Alexandria J. Pharm. Sci.(1992), 6(1), 75-8.
Shafik, Ragab M. et al:Farmaco(1995), 50(4), 273-9.

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