Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-09-02
1995-12-26
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546118, 546121, 560 13, A61K 31435, C07D47104
Patent
active
054788390
ABSTRACT:
To provide a cyclohexane derivative defined by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen or lower alkyl; R.sup.3 represents optionally substituted aryl or optionally substituted heteroaryl; X represents oxygen or sulfur; and Y represents a group represented by the formula: ##STR2## or the like). The compound of the present invention is useful as a preventive and therapeutic agent for diseases against which a potassium channel opening action is efficacious.
REFERENCES:
patent: 5342848 (1994-08-01), Hart et al.
J. Med. Chem., 1993, 36 1604-1612 Brown et al "Syntheses and Biological Activities of Potent Potassium . . . Channel Openers".
Hasegawa Takashi
Ishibashi Keiji
Kabasawa Yasuhiro
Katayama Satoshi
Moriya Katsuhiro
Dentz Bernard
Eisai Co. Ltd.
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