Cycloheptenopyridine derivatives, process for preparation thereo

Details Cycloheptenopyridine derivatives, process for preparation thereo Cycloheptenopyridine derivatives, process for preparation thereo

1990-11-27

1992-09-22

Elmore, Carolyn

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142352, 514299, 514926, 514927, 544127, 546112, 546118, 546183, A61K 3144

Patent

active

051497026

ABSTRACT:
Provided are cycloheptenopyridine derivatives represented by the general formula ##STR1## [wherein R represents a hydrogen atom or lower alkyl group; R.sup.1 represents a hydrogen atom, halogen atom, lower cycloalkoxy group, amido group, substituted phenoxy group, substituted benzyloxy group, lower alkoxy group optionally containing halogen atoms(s), nitro group, hydroxyl group, lower alkenyloxy group, lower alkylthio group, or a group--NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 may be the same or different and each represent a hydrogen atom or lower alkyl group, or R.sup.4 and R.sup.5 mutually combine together with the nitrogen atom adjacent thereto to form a 5- or 6-membered heterocyclic group); R.sup.2 represents a hydrogen atom, halogen atom, lower alkyl group optionally containing a halogen atom, lower alkoxy group optionally containing a halogen atom, hydroxyl group, acyl group, lower alkoxycarbonyl group, nitro group or amino group; R.sup.3 represents a hydrogen atom, a lower alkyl group, lower alkoxymethyl group, lower alkylcarbonyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkylcarbamoyl group, lower alkylcarbonylmethyl group, lower alkoxycarbonyl group, lower acyloxymethyl group, lower alkylsulfonyl group, or physiologically acceptable protective group eliminatable in an acid medium or under a physiological condition; n represents 0 or 1; and A represents a methine carbon or nitrogen atom] or their salts. These derivatives and their salts are useful as antiulcer agents.

REFERENCES:
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patent: 4738970 (1988-04-01), Uchida et al.
patent: 4767769 (1988-08-01), Hockley et al.
patent: 4824856 (1989-04-01), Okabe et al.
patent: 4880815 (1989-11-01), Uchida et al.
Uchida et al., Chem. Pharm. Bull., 37(6), pp. 1517-1523, (1989), (Chem. Abs. only).

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