Cycloheptadiene derivatives

Details Cycloheptadiene derivatives Cycloheptadiene derivatives

1984-01-11

1985-12-31

Reamer, James H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2605011, 26050115, 514529, 560125, 560128, 562506, 562510, 2604109N, 260413, C07C 5703, A61K 31215, C11C 302

Patent

active

045620067

ABSTRACT:
Cycloheptadiene analogues of arachidonic acid as well as their cyclopropyl intermediates are described as inhibiting human leukocyte lipoxygenase and antagonizing SRS-A. Methods of manufacture and pharmaceutical compositions are described. The compounds are useful in treating allergic diseases, cardiovascular diseases and immunoinflammatory diseases.

REFERENCES:
patent: 4294978 (1981-10-01), Sih
patent: 4432906 (1984-02-01), Cohen et al.
patent: 4434101 (1984-02-01), Cohen et al.
patent: 4442099 (1984-04-01), Nicolaou et al.
Urban et al., The Canadian Journal of Microbiology 1981, vol. 27, No. 12, p. 1283.
The Merck Index of Chemicals and Drugs, 7th Edition, 1960 by Merck and Co., Inc., p. 594.

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