Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-06
1997-11-04
Trinh, Ba K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549511, C07D30514
Patent
active
056841698
ABSTRACT:
There is provided an unbranched cyclodextrin or a branched cyclodextrin inclusion complex of taxol. The complex is produced by adding an unbranched cyclodextrin of a branched cyclodextrin to taxol at a molar ratio of 1-20 times with respect to taxol. A method is provided for the improvement of the solubility of taxol in water by adding an unbranched cyclodextrin or a branched cyclodextrin thereto at a molar ratio of 1-20 times with respect to taxol. The solubility of taxol in water is improved by the present invention. A cyclodextrin inclusion complex of taxol according to the present invention serves to make taxol more easily absorbed when administered to a cancer patient, which is beneficial to cancer patients and the physiological effects of taxol may therefore be more effectively induced.
REFERENCES:
patent: 3459731 (1969-08-01), Gramera et al.
patent: 4582900 (1986-04-01), Brandt et al.
patent: 5024998 (1991-06-01), Bodor
patent: 5126333 (1992-06-01), Martini et al.
patent: 5160727 (1992-11-01), Klohs et al.
patent: 5324718 (1994-06-01), Loftsson
D. Duchene, et al, "The Current State of .beta.-Cyclodextrin in Pharmaceutics", (1990), pp. 1-6, Acta Pharmaceutica, vol. 36, No. 1.
Stu Borman, "Taxol To be Made from Renewable Materials by Organic Semisynthesis", Oct. 12, 1992, pp. 30-35, Chemical & Engineering News.
Gunda I. Georg, et al, "Synthesis of Biologically Active Taxol Analogues with Modified Phenylisoserine Side Chains", 1992, pp. 4230-4237, J. Med. Chem., 35.
Francoise Gueritte-Voegelein, et al, "Relationships between the Structure of Taxol Analogues and Their Antimitotic Activity", 1991, pp. 992-998, J. Med. Chem., 34.
Hamada et al AU 645927, Jan. 27, 1994, Derwent Abstract 94-074757.
Hamada Hiroki
Kuwahara Nobuhiro
Mikuni Katsuhiko
Saito Kyoko
Takahashi Hideki
Ensuiko Sugar Refining Co. Ltd.
Trinh Ba K.
LandOfFree
Cyclodextrin inclusion complex of taxol, and method for its prod does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclodextrin inclusion complex of taxol, and method for its prod, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclodextrin inclusion complex of taxol, and method for its prod will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1834207