Cyclodextrin inclusion complex of piperonyl butoxide

Details Cyclodextrin inclusion complex of piperonyl butoxide Cyclodextrin inclusion complex of piperonyl butoxide

1983-11-09

1985-06-18

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514464, 536103, A61K 3173

Patent

active

045240680

ABSTRACT:
The invention relates to new inclusion complexes of piperonyl butoxide formed with cyclodextrin.
The new complex of the invention can be prepared by reacting cyclodextrin or a solution thereof formed with water and/or an organic solvent having 1-4 carbon atoms, preferably ethanol with piperonyl butoxide or a solution thereof formed with an organic solvent having 1-4 carbon atoms, preferably ethanol at a temperature between 20.degree. C. and 90.degree. C., whereby the piperonyl butoxide is used in an amount of 0.6-1.5 moles related to 1 mole of cyclodextrin.
The complexes of the present invention synergize the pesticidal effect of known insecticides and fungicides to a much higher extent of known insecticides and fungicides to a much higher extent than piperonyl butoxide used per se.

REFERENCES:
patent: 4228160 (1980-10-01), Szejtli et al.
patent: 4407795 (1983-10-01), Nicolau et al.
patent: 4424209 (1984-01-01), Tuttle
The Merck Index 9th Ed. (1976), p. 7273, No. 7270.

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