Cyclodextrin/drug complexation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536103, 5147722, 5147723, 5147726, 514773, 514777, 514779, 514781, A61K 31735, C08B 3716

Patent

active

053247183

ABSTRACT:
The invention provides a method for enhancing the complexation of a cyclodextrin with a lipophilic and/or water-libile drug, comprising combining from about 0.1 to about 70% (weight/volume) of a cyclodextrin and from about 0.01 to about 5% (weight/volume) of a pharmaceutically acceptable, pharmacologically inactive, water-soluble polymer in an aqueous medium with a lipophilic and/or water-labile drug to form a drug complex, optionally followed by removal of water. Related methods, co-complexes of drug/cyclodextrin/polymer, pharmaceutical compositions and cyclodextrin/polymer complexing agents are also provided.

REFERENCES:
patent: 3459731 (1969-08-01), Gramera et al.
patent: 4596795 (1986-06-01), Pitha
patent: 4727064 (1988-02-01), Pitha
patent: 4834985 (1989-05-01), Elger et al.
patent: 4983586 (1991-01-01), Bodor
patent: 5002935 (1991-03-01), Bodor
patent: 5017566 (1991-05-01), Bodor
patent: 5024998 (1991-06-01), Bodor
patent: 5120546 (1992-06-01), Hansen et al.
Villiers, C. R. Acad. Sci., 112, 536-538(1891).
Schardinger, Z. Unters. Nahr. Genussm., 6, 865-880(1903).
Szejtli, Pharm. Techn. Int., 3(2), 15-22(1991).
Szejtli, Pharm. Techn. Int., 3(3), 16-24(1991).
Loftsson et al., Pharm. Ztg. Wiss., 4/136:5-10(1991).
Hirayama et al., in Cyclodextrins and their industrial uses, ed. D. Duchene, Editions de Sante, Paris, 1987, pp. 133-172.
Hassan et al., Int. J. Pharm. 58, 19-24(1990).
Nakai et al., Chem. Pharm. Bull, 35(11), 4609-4615(1987).
Nakai et al., Chem. Pharm. Bull, 37(4), 1055-1058(1989).
Nakai et al., Chem. Pharm. Bull, 38(3), 728-732(1990).
Nakai et al., Chem. Pharm. Bull., 38(5), 1345-1348(1990).
Nakai et al., Chem. Pharm. Bull., 39(6), 1532-1535(1991).
Schmidt et al., Starch/Starke, 39(6), 203-207(1987).
Loftsson et al., Acta. Pharm. Nord, 1(4), 185-193(1989).
Remington's Pharmaceutical Sciences, 18th edition, Alfonso R. Gennaro (ed.), Mack Publishing Co., Easton, PA, 1990, pp. 291-294.
Martin et al., Physical Pharmacy, 3rd edition, Lea & Febinger, Philadelphia, PA, 1983, pp. 592-638.
Florence et al., Physicochemical Principles of Pharmacy, 2nd edition, MacMillan Press, London, 1988, pp. 281-334.
Leung et al., in Controlled Drug Delivery, 2nd edition, Robinson and Lee, editors, Marcel Dekker, Inc., New York, 1987, pp. 433-480.
Uekama et al, Journal of Inclusion Phenomena, 1, 309-312 (1984).
J. S. Pagington, "B-cyclodextrin; the success of molecular inclusion", Chemistry in Britain, May 1987, pp. 455-458.
STN Filer Supplier & File Medline AN=92324215 (Orienti et al.).
Chemical Abstracts, vol. 107, No. 16, 1987, abstract No. 140916f.
Database WPI, Week 9037, Derwent Publication Ltd., London, GB, AN 90-279330.
Loftsson et al, Eur. J. Pharm. Biopharm., vol. 37, No. 1, Mar. 1991, 30--33.
The Merck Index, eleventh edition, ed. Susan Budavari et al, Merck & Co., Inc., Rahway, N.J., 1989, pp. 959, 1248 and 1467.
Cosmetic and Drug Preservation: Principles and Practice, ed. Jon J. Kabara, Marcel Dekker, Inc., New York, N.Y., 1984, pp. 71-72.
The United States Pharmacopeia, USP XXII, twenty-second revision, Jan. 1, 1990, U.S. Pharmacopeial Convention, Inc., Rockville, Md., p. 8.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cyclodextrin/drug complexation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclodextrin/drug complexation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclodextrin/drug complexation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2377566

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.