Cyclodextrin complexes for neuraxial administration of drugs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536103, A61K 3156, C08B 3716

Patent

active

051807165

ABSTRACT:
A method of delivering a drug to a patient, comprising administering said drug to the neuraxis of said patient in the form of a complex between said drug and a cyclodextrin, the cyclodextrin comprising at least one substituent to reduce crystallization of the complex or the cyclodextrin. Compositions suitable for carrying out the method are also disclosed.

REFERENCES:
patent: 4599327 (1986-07-01), Nogradi et al.
patent: 4603123 (1986-07-01), Chiesi et al.
patent: 4727064 (1988-02-01), Pitha
patent: 4816462 (1989-03-01), Nowicky
patent: 4834985 (1989-05-01), Elger et al.
patent: 4869904 (1989-09-01), Uekama et al.
patent: 4983586 (1991-01-01), Bodor
patent: 4983636 (1991-01-01), Takeuchi et al.
patent: 5002935 (1991-03-01), Bodor
patent: 5008386 (1991-04-01), Szabo et al.
patent: 5017566 (1991-05-01), Bodor
Anderson, W. R. et al., 1988. Drug Design and Delivery 2: 287-298.
Yaksh, T. L. et al., 1986. Anesthesiology 64: 54-66.
Koizumi, K. et al., 1981. J. Chromatography 205: 401-412.
Pitha et al., "Drug Solubilizers to Aid Pharmacologists: Amorphous Cyclodextrin Derivatives," Life Sciences, 43:493-502 (1988).
Pitha et al., "Hydroxypropyl-.beta.-Cyclodextrin: Preparation and Characterization; Effects on Solubility of Drugs," International Journal of Pharmaceutics, 29:73-82 (1986).
Joseph Pitha, "Cyclodextrins: Solutions to Insolubility," Neurotransmissions, 5:1-4 (1989).
A. F. Casy et al., "Application of Cyclodextrins to Chiral Analysis by .sup.1 H N M R Spectroscopy," Magn. Reson. Chem., 26:765-774 (1988).
Kawasaki et al., "Prostaglandin E.sub.2 . .beta.-Cyclodextrin (PGE.sub.2 . CD) Pharmacological Studies on .beta.-Cyclodextrin Clathrate Compound of Prostaglandin E.sub.2 (PGE.sub.2 . CD)," Pharmacometrics (Tokyo), 8:61-83 (1974).
C. Simone et al., "Beta -Cyclodextrin-Piroxicam: Efficacy and Tolerability in the Treatment of Pain After Bone and Joint Surgery," Current Therapeutic Research, 47:541-547 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cyclodextrin complexes for neuraxial administration of drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclodextrin complexes for neuraxial administration of drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclodextrin complexes for neuraxial administration of drugs will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-102178

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.