Cyclodextrin-based polymers for therapeutics delivery

Details Cyclodextrin-based polymers for therapeutics delivery Cyclodextrin-based polymers for therapeutics delivery

2007-09-18

2007-09-18

Maier, Leigh C. (Department: 1623)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

C424S280100, C525S238000

Reexamination Certificate

active

10656838

ABSTRACT:
The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

REFERENCES:
patent: 4291013 (1981-09-01), Wahlig et al.
patent: 4347234 (1982-08-01), Wahlig et al.
patent: 4438253 (1984-03-01), Casey et al.
patent: 4525495 (1985-06-01), Dorman et al.
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4570629 (1986-02-01), Widra
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4587268 (1986-05-01), Pfirrmann
patent: 4638045 (1987-01-01), Kohn et al.
patent: 4652441 (1987-03-01), Okada et al.
patent: 4675381 (1987-06-01), Bichon
patent: 4745160 (1988-05-01), Churchill et al.
patent: 5100669 (1992-03-01), Hyon et al.
patent: 5183883 (1993-02-01), Tanaka et al.
patent: 5219980 (1993-06-01), Swidler
patent: 5276088 (1994-01-01), Yoshinaga
patent: 5330768 (1994-07-01), Park et al.
patent: 5855900 (1999-01-01), Nobuhiko
patent: 6048736 (2000-04-01), Kosak
patent: 6509323 (2003-01-01), Davis et al.
patent: 7141540 (2006-11-01), Wang et al.
patent: 2002/0151523 (2002-10-01), Davis et al.
patent: 2003/0008818 (2003-01-01), Pun et al.
patent: 2003/0017972 (2003-01-01), Pun et al.
patent: 0 258 780 (1988-03-01), None
patent: 0 730 869 (1996-09-01), None
patent: 2 665 169 (1992-01-01), None
patent: WO-91/13100 (1991-09-01), None
patent: WO93/24150 (1993-12-01), None
patent: WO-98/47496 (1998-10-01), None
patent: WO99/61062 (1999-12-01), None
patent: WO-00/01734 (2000-01-01), None
patent: WO 00/33885 (2000-06-01), None
patent: WO 2004/039869 (2004-05-01), None
Minani, K. et al “Colon-specific drug delivery based on a cyclodextrin pro-drug . . . ” J. Pharm. Sci. (1998) vol. 87, No. 6, pp. 715-720.
Yano, H. et al “Preparation of prednisolone-appended alpha-, beta-, and gamma-cyclodextrins . . . ” J. Pharm. Sci. (2001) vol. 4, pp. 493-503.
U.S. Appl. No. 09/339,818, filed Jun. 25, 1999, Davis, et al.
U.S. Appl. No. 09/453,707, filed Dec. 3, 1999, Davis, et al.
U.S. Appl. No. 10/372,723, filed Feb. 24, 2003, Bellocq, et al.
U.S. Appl. No. 60/417,373, filed Oct. 9, 2002, Bellocq, et al.
Melton, L.D. and Slessor, K.N., Carbohydrate Research, 18, p. 29 (1971).
Mungall et al., J. Org. Chem. 1659-1662.
Tabushi et al., Tetrahedron Lett. 18:1527-1530 (1977).
D. F. Williams, J. Mater. Sci. 1233 (1982).
Tabushi et al., J. Am. Chem. Soc. 106, 5267-5270 (1984).
Tabushi et al., J. Am. Chem. Soc. 106, 4580-4584 (1984).
Hisamatsu et al., Starch 44:188-191 (1992).
Husain et al., Applied Spectroscopy, 46:652-658 (1992).
T. Cserhati, Analytical Biochemistry, 225:328-332 (1995).
Putnam, et al., Nature Med. 824-826 (1996).
Zhang et al., J. Am. Chem. Soc. (1997), 119, 1676-1681.
Suh, J. and Noh, Y., Bioorg. Med. Chem. Lett. (1998), 8, 1327-1330.
Comprehensive Supramolecular Chemistry, vol. 3, J.L. Atwood et al., eds., Pergamon Press (1996) table of contents only.
Yano H et al: Journal of Controlled Release, vol. 79, No. 1-3 (2002) pp. 103-112.
Hristova-Kazmierski M K et al: Bioorangic and Medicinal Chemistry Letters, vol. 3 No. 5 (1993) pp. 831-834.
Huh, K.M. et al: Macromolecular Rapid Communications , vol. 23, No. 3, (2002).
Ortega-Caballero F et al: Journal of Organic Chemistry vol. 66 No. 23, pp. 7786-7795 (2001).
Ashton et al., “Amino Acid Derivatives of β-Cyclodextrin,” J. Org. Chem. 61:903-908 (1996).
Song et al., “Catalyzed Hydrolysis of RNA by Metallic Complexes of β-Cyclodextrin Derivative,” Journal of Molecular Catalysis (China) 15(2):139-142 (2001).

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