Cyclobutyl oligonucleotide surrogates

Details Cyclobutyl oligonucleotide surrogates Cyclobutyl oligonucleotide surrogates

1991-12-13

1994-10-25

Yarbrough, Amelia Burgess

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 2431, 536 2432, 544243, C07H 2104

Patent

active

053590449

ABSTRACT:
Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed.

REFERENCES:
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5087617 (1992-02-01), Smith
Cohen in Oligonucleotides: Antisense Inhibitors of Gene Expression, CRC Press, Inc. Boca Raton, FL (1989).
Miller, P. S. and Ts'O, P.O.P. (1987) Anti-Cancer Drug Design, 2:117-128.
Goodchild, J. (1990) Bioconjugate Chemistry, 1:165
Uhlmann, E. and Peyman, A., (1990) Chemical Reviews, 90:543.
Norbeck, D. W., et al. (1990) J. Med. Chem., 33:1281.
Hayashi, S., et al. (1990) Antimicrobial Agents and Chemotherapy, 34:287.
Boumchita, H., Legraverenc, M., Huel, C. and Bisagni, E. (1990) J. Heterocyclic Chem. 27:1815.
Van Boom, J. H., et al. Chemical and Enzymatic Synthesis of Gene Fragments, A Laboratory Manual, edited by H. G. Gassen and Anne Lang, Verlag Chemie Weinhiem/Deerfield Beach, FL/Basel 1982.
Maruyama, T., et al. (1990) J. Chem. Pharm. Bull., 38:2719.
Boumchita, H., Legraverend, M., Huel, C. and Bisagni, E. (1990) J. Heterocyclic Chem., 27:1815.
Radhakrishnan, P. I., Egan, W., Regan, J. B. and Beaucage, S. L., (1990), J. Am. Chem. Soc., 112:1253.
Pfitzer, K. E. and Moffat, J. G. (1963) J. Am. Chem. Soc., 85:3027.
Musicki, B and Widlanski, T. S. (1990) J. Organic Chem., 55:4231.
Gryaznov, S. M. and Sokolova, N. I. (1990) Tetrahedron Letters, 31:3205.
Matteucci, M. (1990) Tetrahedron Letters, 31:2385.
Mazur, A., Troop, B. E. and Engel, R. (1984) Tetrahedron, 40:3949.
Stirchak, E. P. and Summerton, J. E. (1987) J. Organic Chem., 52:4202.
Li, C and Zemlicka (1977) J. Organic Chem., 42:706.
Nyilas, A., Glemare, C. and Chattopadhyaya, J. (1990) Tetrahedron, 46:2149.
Veeneman, G. H., et al. (1990) Recl. Trav. Chim. Pays-Bas, 109:449.
Ogilvie, K. K. and Cormier, J. F. (1985) Tetrahedron Letters, 26:4159.
Avram, M., Nenitzescu, C. D. and Maxim, C. D. (1957) Chem. Ber., 90:1424.
Safanda, J. and Sobotka, P. (1982) Collect. Czech. Chem. Commun. 47:2440.
Henlin et al., "Synthesis of Octameric Phosphodiesters of [3,3-Bis(hydroxymethyl)cyclobutyl]adenine and -Thymine as Well as Their Hybridization Properties", Angewandte vol. 31, No. 4: 482-484 (1992).
Henlin et al., "Synthesis of 3-Adenyl-- and 3-Thyminylcyclobutane-1, 1-dimethanols and Their Homo-octameric Phosphodiesters", Helvetica Chimica Acta vol. 75 (1992) pp. 589-603.

Affiliated with

Also associated with

Rating

Cyclobutyl oligonucleotide surrogates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclobutyl oligonucleotide surrogates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclobutyl oligonucleotide surrogates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-136315