Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-03-13
1993-02-16
Elmore, Carolyn
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514 63, 514351, 514357, 514512, 514575, 514469, 514470, 514471, 514438, 514443, 514336, 546283, 546284, 546291, 546332, 546300, 549 51, 549 54, 549 55, 549 58, 549 65, 549 76, 549 77, 549467, 549493, 549469, 549479, 560313, 562621, 562622, 562623, 562874, 556436, 558262, 552 35, A61K 3138, C07D33234, C07D33232
Patent
active
051871920
ABSTRACT:
Compounds of the structure ##STR1## where M is a pharmaceutically acceptable cation or a metabolically cleavable group, R is alkyl, cycloalkyl or --NR.sup.1 R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted alkyl, cycloalkyl, carbocyclic aryl, benzo[b]furyl, thienyl, or benzo[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
REFERENCES:
patent: 4738986 (1988-04-01), Keen et al.
patent: 4988733 (1991-01-01), Salmon et al.
patent: 5120752 (1992-06-01), Brooks et al.
Brooks Dee W.
Rodriques Karen E.
Abbott Laboratories
Brooks Dee W.
Elmore Carolyn
Rodriques Karen E.
Russell Mark W.
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