Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives

Details Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives

1999-04-09

2000-12-05

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

560 13, 560312, 562427, 562430, C07C 31195, C07C31714

Patent

active

061567981

ABSTRACT:
A compound of the formula ##STR1## wherein Y and R.sup.1 are defined in the specification, useful in the treatment of arthritis or cancer and other diseases involving selective inhibition of matrix metalloproteinase-13.

REFERENCES:
patent: 5672615 (1997-09-01), MacPherson et al.
Database Caplus on STN, Acc. No. 1998:147308, Blumenkopf et al., `Preparation of arylsulfonylaminohydroxamic acid derivatives as inhibitors of matrix metalloproteinase and production of tumor necrosis factor.` WO 9807697 A1 (abstract), Feb. 26, 1998.
Database Caplus of STN, Acc. No. 1999:468334, McClure et al., `Matrix metalloprotease (MMP)-13 selective inhibitors for treatment of arthritis deformans and other MMP-related diseases.` JP 11199512 A2 (abstract), Jul. 27,1999.
Database Caplus on STN, Acc. No. 1999:464012, Doherty, `MMP inhibitors for the treatment of ocular angiogenesis.` EP 930067 A2 (abstract), Jul. 21, 1999.
Database Caplus on STN, Acc. No. 1999:126875, Robinson, `Preparation of aryloxyarylsulfonylaminohydroxamic acid derivatives as inhibitors of matrix metalloproteinase-13.` WO 9907675 A1 (abstract), Feb. 18, 1999.
Database Caplus on STN, Acc. No. 1998:543047, Robinson et al., `Preparation of arylsulfonylaminoalkylhydroxamates as inhibitors fo matrix metalloproteinases or tumor necrosis factor production.` WO 9833768 A1 (abstract), Aug. 6, 1998.

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