Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfonate esters
Patent
1991-02-19
1992-07-14
Cintins, Marianne
Organic compounds -- part of the class 532-570 series
Organic compounds
Sulfonate esters
558 44, 558 57, 556428, 556482, 560 81, 560105, 560106, 560123, 560266, 568660, 568661, 568662, 568663, C07C30930, C07C 6976, C07F 708
Patent
active
051304627
ABSTRACT:
Cyclobutane derivatives of the formulas ##STR1## wherein P is a hydroxy protecting group and X is a leaving group are useful intermediates in the preparation of antiviral compounds.
REFERENCES:
patent: 4177348 (1979-12-01), Shealy et al.
patent: 4232154 (1980-11-01), Shealy et al.
patent: 4617304 (1986-10-01), Ashton et al.
patent: 4743689 (1988-05-01), Shimada
patent: 4782062 (1988-11-01), Tolman et al.
patent: 4801710 (1989-01-01), MacCoss et al.
patent: 4855466 (1989-08-01), Zahler et al.
patent: 4918075 (1990-04-01), Zahler et al.
patent: 4968674 (1990-11-01), Taniyama et al.
patent: 5064961 (1991-11-01), Bisacchi et al.
N. Shimada et al., Oxetanocin, A Novel Nucleoside from Bacteria, Nov. 1986, J. Antibiotics 39, p. 1623.
N. Nakamura et al., The X-Ray Structure Determination of Oxetanocin, Nov. 1986, J. Antibiotics, 39, p. 1626.
H. Hoshino et al., Inhibition of Infectivity of Human Immunodeficiency Virus by Oxetanocin, Jul. 1987, J. Antibiotics, 40, p. 1077.
S. Niitsuma et al., Studies on the Total Synthesis of Oxetanocin; Tetrahedron Letters, vol. 28, pp. 4713-4714, May 1987.
G. N. Austin et al., Chiral Oxetanes from Sugar Lactones, Tetrahedron Letters, vol. 28, pp. 4741-4744, May 1987.
N. Shimada et al.--Derivatives of Oxetanocin: Oxetanocins, H, X ang G, and 2-Aminooxetanocin A, J. Antibiotics, vol. 40, p. 1789, Dec. 1987.
Walton, "3-Methylenecyclobutyl, Cyclopent-3-enyl . . . ", J. Chem. Soc. Perkin Trans II 1987 pp. 231-235.
Kirmse et al., "2-Oxabicyclo[2.1.1]hexan . . . ", Chemische Berichte, vol. 121, No. 5, 1988, pp. 1013-1016.
Hanack et al., "Solvolysan von delta.sup.2 -cyclobutylmethyltosylat", Chemische Berichte, vol. 100, No. 6, 1967, pp. 2107-2116.
DeClerq, "Pyrimidine Nucleoside Analogs As Antiviral Agents" Targets For The Design of Antiviral Agents, 1983, pp. 203-230.
Bamford et al., "Synthesis and Antiviral Activity . . . " J. Med. Chem., 1990, vol. 33, pp. 2494-2501.
Kono et al., "Substrate Specificity Of A Thymidine . . . " Chem. Pharm. Bull., vol. 32 (1984), pp. 1919-1921.
March, "Advanced Organic Chemistry", 1985, p. 129.
Niitsuma et al., "Studies On The Total Synthesis . . . " Tetrahedron Letters, vol. 28, pp. 3967-3970 (1987).
Marquez et al. "Carbocyclic Nucleosides", Medicinal Research Review, vol. 6, pp. 1-16 and 36-40.
Shealy et al., "Synthesis and Antiviral Activity . . . ", J. Med. Chem., vol. 27, pp. 1416-1421 (1984).
Slusarchyk William A.
Zahler Robert
Argo Margaret J.
Cintins Marianne
Davis Stephen B.
E. R. Squibb & Sons Inc.
LandOfFree
Cyclobutane derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclobutane derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclobutane derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-335958