Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants

Details Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants

1994-06-10

1996-03-19

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548454, A61K 3140, C07D20934

Patent

active

055004423

ABSTRACT:
The present invention relates to novel cyclobut-3-ene-1,2-dione-3-yl substituted benzopyrans, indanes and tetrahydronaphthalenones having smooth muscle relaxant activity, pharmaceutical compositions containing them, and to their use in the treatment of diseases and disorders involving excessive smooth muscle contractions in the cardiovascular system, urinary tract, pulmonary system, or gastrointestinal tract.
The compounds of this invention are represented by Formula (I): ##STR1## wherein: the substituents are as defined herein.

REFERENCES:
patent: 4616021 (1986-10-01), Ashwood
patent: 4908378 (1990-03-01), Soll
patent: 4925839 (1990-05-01), Quagliato
patent: 4983612 (1991-01-01), Quagliato
patent: 5208246 (1993-05-01), Almansa
Liebeskind and Fengl, J. Org. Chem. 55, 5359-5364 (1990).

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