Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-12-11
1977-07-26
Curtis, Allen B.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2603437, 26050117, 424280, 424316, 424322, A61K 3117, C07C12719, C07C12715
Patent
active
040383130
ABSTRACT:
Compounds selected from the group consisting of amines of the formula I ##STR1## in which R.sub.1 and R.sub.2 stand for a member selected from lower alkyl, lower alkenyl, cycloalkyl having 4 to 7 ring members, phenyl-lower alkyl, phenyl-lower alkyl substituted in the phenyl residue by a member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, lower alkylene, oxa-lower alkylene, aza-lower alkylene and thia-lower alkylene, and one of R.sub.1 and R.sub.2 stands for hydrogen and the other has the above meanings, Ph stands for a member selected from meta- and para-phenylene and meta- and para-phenylene substituted by a member selected from lower alkyl, lower alkenyl, lower alkinyl, mercapto-lower alkyl, hydroxy-lower alkyl, phenyl, cyano, hydrogen, halogen, lower alkoxy, lower alkenyloxy, lower alkinyloxy, mono-, di and trihalogeno-lower alkyl, cycloalkyl having 5 to 7 ring members and phenoxy, and R.sub.3 stands for a member selected from lower alkyl and cycloalkyl having 5 to 7 ring members, and their condensation product with aldehydes and ketones, and their salts are useful as agents for the inhibition of the cardiac .beta.-receptors.
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Smith, CA 78:71716j (1973).
Ciba-Geigy Corporation
Curtis Allen B.
Groeger Theodore O.
Kolodny Joseph G.
Maitner John J.
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