Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-07-02
1993-12-28
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548201, 548204, A61K 31425, C07D27728, C07D27730
Patent
active
052739864
ABSTRACT:
Compounds of the formula: ##STR1## wherein the substituents are as described in the specification, antagonize LTD.sub.4 action and thus, are useful in treating bronchial asthma, pulmonary anaphylaxis, cystic fibrosis, chronic bronchitis, bronchiectasis, respiratory distress syndrome and pulmonary oedema.
REFERENCES:
patent: 4902700 (1990-02-01), Hayashi et al.
patent: 4925861 (1990-05-01), Hayashi et al.
patent: 5001140 (1991-03-01), Field et al.
Chemical Abstracts vol. 114, Abst. 6492b (1991).
Jpn. J. Pharmacol (1989) 50 (1) 37-46.
Holland George W.
Vermeulen John R.
Zally William J.
Brust Joseph Paul
Ciambrone Coletti Ellen
Gabilan MarySusan H.
Gould George M.
Hoffmann-La Roche Inc.
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