Cycloalkylthiazoles

Details Cycloalkylthiazoles Cycloalkylthiazoles

1993-09-02

1995-03-21

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548201, 548204, 548205, 548202, C07D27722

Patent

active

053997026

ABSTRACT:
Compounds of the formula: ##STR1## wherein the substituents are as defined herein, and enantiomers, diastereomers, racemates and salts with pharmaceutically acceptable bases, antagonize LTD.sub.4 action and thus, are useful in treating bronchial asthma, pulmonary anaphylaxis, cystic fibrosis, chronic bronchitis, bronchiectasis, respiratory distress syndrome and pulmonary oedema.

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patent: 4933328 (1990-06-01), Curtze et al.
patent: 5001140 (1991-03-01), Field et al.
Tetrahedron vol. 44, No. 7, 1988 pp. 2021-2031.
Liebigs Annalen der Chemie No. 4, 1981 pp. 623-632.
Jpn.J.Pharmacol (1989) 50(1) 37-46.
Chemical Abstracts vol.114:6492f Preparation of 2-styrylthiazole and benzothiazole derivatives as leukotriene antagonists (1991).

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