Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-08-14
1990-06-05
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514923, 546 69, A61K 3148, C07D45706
Patent
active
049314475
ABSTRACT:
This invention provides (8.beta.)-N-cycloalkyl-1-alkyl-6-(substituted) ergoline-8-carboxamides useful for blocking 5HT.sub.2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating hypertension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.
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Foreman Mark M.
Garbrecht William L.
Marzoni Gifford P.
Whitten Kathleen R.
Conrad Robert A.
Eli Lilly and Company
Shen Cecilia
Whitaker Leroy
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