Cycloalkylalkylamines which are sigma-receptor ligands and their

Details Cycloalkylalkylamines which are sigma-receptor ligands and their Cycloalkylalkylamines which are sigma-receptor ligands and their

1993-07-29

1994-07-05

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514462, 514528, 514640, 514657, 549331, 549336, 549401, 549404, 558415, 558418, 564265, 564378, A61K 31135, A61K 3135, C07C21119, C07D31174

Patent

active

053267842

ABSTRACT:
New cycloalkylalkylamines which are sigma-receptor ligands of formule (I) ##STR1## in which: R.sub.1 is H or lower alkyl; X and Y are H, OH, lower alkyl, lower alkoxy, halogen or nitrile; V.sub.1 and V.sub.2 together form a double bond attached to an oxygen atom or to a hydroxyimino radical, or are linked as an ethylenedioxy chain; A represents a valency bond, an oxygen atom, a methylene or an ethylene group; m is equal to 0, 1 or 2; n has the value of an integer from 1 to 5. Psychotropic drug which is also useful in gastroenterology.

REFERENCES:
patent: 5180746 (1993-01-01), Goto et al.
Welch et al, J. Med. Chem. (1977), vol. 20, No. 5, pp. 699-705.
Krotov et al, Chemical Abstracts, vol. 52 (1958) 20677b.

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