Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-08-28
2007-08-28
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S326000, C514S418000, C546S187000, C548S486000
Reexamination Certificate
active
11077355
ABSTRACT:
The present invention relates to cycloalkyl-containing 5-acylindolinones of general formulawherein R1to R3are defined as in claims1to6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
REFERENCES:
patent: 7176231 (2007-02-01), Heckel et al.
patent: WO 01/27080 (2001-04-01), None
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Sato, N., et al. “Maintenance of Pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor”, Nature Medicine, vol. 10, pp. 55-63, 2004.
Heckel Armin
Hoerer Stefan
Kley Jörg
Roth Gerald Jürgen
Uphues Ingo
Barker Michael
Boehringer Ingelheim International GmbH
Devlin Mary-Ellen M.
Dow David
Morris Michael
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