Cycloalkyl-substituted glutaramide diuretic agents

Details Cycloalkyl-substituted glutaramide diuretic agents Cycloalkyl-substituted glutaramide diuretic agents

1989-05-08

1990-10-02

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514484, 514488, 514510, 514530, 514562, 514563, 560 10, 560 13, 560 27, 560 28, 560 37, 560115, 560118, 562427, 562430, 562443, 562444, 562449, 562450, 562500, C07C10136, A61K 31215

Patent

active

049607928

ABSTRACT:
2-Acylaminoalkyl-3-[1-(carboxycycloalkylcarbamoyl)cycloalkyl]propanoic acid derivatives (which may also be viewed as glutaramide derivatives) are useful in the treatment of hypertension, heart failure and renal insufficiency, based upon their inhibition of zinc-dependant, neutral endopiptidase.

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