Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory

Details Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory

1993-08-25

1994-07-05

Dees, Jose'G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

562623, 562624, A01N 5502

Patent

active

053267877

ABSTRACT:
Compounds of the structure ##STR1## where M is hydrogen, a pharmaceutically acceptable cation or metabolically cleavable group, R is alkyl, cycloalkyl, or NR.sup.1 R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl alkonyl, or carbocyclic aryl, Y is alkylene, alkenylene, or cyclopropyl, and A is optionally substituted cycloalkyl or cycloalkylene are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

REFERENCES:
patent: 4299778 (1981-11-01), Pilgram
patent: 4728670 (1988-03-01), Haslanges et al.
patent: 5155127 (1992-10-01), Trivedi
patent: 5214204 (1993-05-01), Dellaria et al.
Summers, "Preparation of Urea-based Lipoxygenes inhibiting compounds" EP 292699A2. Nov. 30, 1989; CA110(19):172898e. Abstract Only.
Summers et al, "Structure-activity analysis of a clsss of orally active hydroxamic acid inhibitors of Leukotriene biosynthesis", J. Med. Chem. 31(10), 1960-4 (1988) Chemical Abstract citation only (CA109(17):1490129.).

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