Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-12-26
2006-12-26
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S212070, C540S522000, C540S523000
Reexamination Certificate
active
07153847
ABSTRACT:
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
REFERENCES:
patent: 2938029 (1960-05-01), Brenner et al.
patent: 3598859 (1971-08-01), Yates et al.
patent: 3657341 (1972-04-01), Thorne, et al.
patent: 4080449 (1978-03-01), Croisier et al.
patent: 4410520 (1983-10-01), Watthey
patent: 4460579 (1984-07-01), Karenewsky
patent: 4473575 (1984-09-01), Watthey
patent: 4477464 (1984-10-01), Slade et al.
patent: 4666829 (1987-05-01), Glenner et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 5015639 (1991-05-01), Berger et al.
patent: 5206235 (1993-04-01), Fisher et al.
patent: 5238932 (1993-08-01), Flynn et al.
patent: 5247080 (1993-09-01), Berger et al.
patent: 5283241 (1994-02-01), Bochis et al.
patent: 5284841 (1994-02-01), Chu et al.
patent: 5324726 (1994-06-01), Bock et al.
patent: 5360802 (1994-11-01), Chambers et al.
patent: 5420271 (1995-05-01), Warshawsky et al.
patent: 5478857 (1995-12-01), Clemens et al.
patent: 5486541 (1996-01-01), Sterling et al.
patent: 5502048 (1996-03-01), Chapdelaine et al.
patent: 5519061 (1996-05-01), Youdim et al.
patent: 5532415 (1996-07-01), Youdim et al.
patent: 5556969 (1996-09-01), Chambers et al.
patent: 5633251 (1997-05-01), Claremon et al.
patent: 5656626 (1997-08-01), Chapdelaine et al.
patent: 5658901 (1997-08-01), Claremon et al.
patent: 5672598 (1997-09-01), De et al.
patent: 5712397 (1998-01-01), Esser et al.
patent: 5770573 (1998-06-01), Arrhenius et al.
patent: 1 063 108 (1979-09-01), None
patent: 0 061 187 (1982-09-01), None
patent: 0 167 919 (1986-01-01), None
patent: 0 284 256 (1988-09-01), None
patent: 0 349 949 (1990-01-01), None
patent: 0 376 849 (1990-07-01), None
patent: 0 434 360 (1991-06-01), None
patent: 0 434 364 (1991-06-01), None
patent: 0 434 369 (1991-06-01), None
patent: 0 490 590 (1992-06-01), None
patent: 0 514 133 (1992-11-01), None
patent: 0 523 845 (1993-01-01), None
patent: 0 549 039 (1993-06-01), None
patent: 0591529 (1994-04-01), None
patent: 0 647 632 (1995-04-01), None
patent: 0647632 (1995-04-01), None
patent: 0 652 009 (1995-06-01), None
patent: 0 667 344 (1995-08-01), None
patent: 0 677 517 (1995-10-01), None
patent: 0 732 399 (1996-09-01), None
patent: 0 778 266 (1997-11-01), None
patent: 810221 (1997-12-01), None
patent: 0945445 (1999-09-01), None
patent: 1 519 931 (1977-01-01), None
patent: 1 519 931 (1978-07-01), None
patent: 1519495 (1978-07-01), None
patent: 1 573 931 (1980-08-01), None
patent: 2 272 439 (1994-05-01), None
patent: 2 290 788 (1996-01-01), None
patent: 71515 (1995-12-01), None
patent: 5247033 (1993-09-01), None
patent: 06145148 (1994-05-01), None
patent: 04210967 (1994-08-01), None
patent: 6211812 (1994-08-01), None
patent: 07304770 (1995-11-01), None
patent: 10072444 (1998-03-01), None
patent: 179757 (1998-04-01), None
patent: 1010560 (1998-04-01), None
patent: 95/03290 (1990-02-01), None
patent: 92/01683 (1992-02-01), None
patent: WO 92/11246 (1992-07-01), None
patent: 92/16524 (1992-10-01), None
patent: WO 92/16524 (1992-10-01), None
patent: 93/19052 (1993-09-01), None
patent: 93/19063 (1993-09-01), None
patent: WO 94/00438 (1994-01-01), None
patent: 94/04531 (1994-03-01), None
patent: 94/05693 (1994-03-01), None
patent: 94/07486 (1994-04-01), None
patent: 94/10569 (1994-05-01), None
patent: WO 94/25445 (1994-11-01), None
patent: 95/03289 (1995-02-01), None
patent: WO 95/03285 (1995-02-01), None
patent: 95/09838 (1995-04-01), None
patent: 95/14671 (1995-06-01), None
patent: 95/21840 (1995-08-01), None
patent: 95/23810 (1995-09-01), None
patent: 95/25118 (1995-09-01), None
patent: WO 95/25117 (1995-09-01), None
patent: 95/32191 (1995-11-01), None
patent: 96/05839 (1996-02-01), None
patent: 96/16981 (1996-06-01), None
patent: 96/19492 (1996-06-01), None
patent: 96/20725 (1996-07-01), None
patent: 96/22966 (1996-08-01), None
patent: WO 96/25408 (1996-08-01), None
patent: WO 96/29313 (1996-09-01), None
patent: 96/40146 (1996-12-01), None
patent: 96/40653 (1996-12-01), None
patent: 96/40654 (1996-12-01), None
patent: 96/40655 (1996-12-01), None
patent: 96/40656 (1996-12-01), None
patent: WO 97/16410 (1997-05-01), None
patent: 97/30072 (1997-08-01), None
patent: 97/38705 (1997-10-01), None
patent: WO 97/38705 (1997-10-01), None
patent: 98/00405 (1998-01-01), None
patent: WO 98/04539 (1998-02-01), None
patent: WO 98/22430 (1998-05-01), None
patent: WO 98/22433 (1998-05-01), None
patent: WO 98/22494 (1998-05-01), None
patent: 98/25930 (1998-06-01), None
patent: WO 88/25911 (1998-06-01), None
patent: 98/28268 (1998-07-01), None
patent: 98/38177 (1998-09-01), None
patent: WO 98/38177 (1998-09-01), None
Akhatar, et al., “Bicyclic Imides with Bridgehead Nitrogen..”,J. Org. Chem., 55: pp. 5222-5225 (1990).
Armstrong, et al., “An Efficient Asymmetric Synthesis of (R)-3-Amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one”.Tetrahedron Letters, 35: pp. 3239-3242 (1994).
Barton, et al., “A New Rearrangement of Ketonic Nitrones . . . ”,J. Chem. Soc., pp. 1764-1767 (1975).
Ben-Ishai, et a., “Intra vs Intermolecular Amidoalkylation of Aromatics”,Tetrahedron, 43:2, pp. 439-450 (1987).
Blade-Font, “Facile Synthesis of γ-,δ-, and ε-lactams by Cyclodehydration of ω-amino Acids on Alumina or Silica Gel”,Tetrahedron Letters, 21:2443-2446 (1980).
Brown, et al., “A Revision of the Structure of 7-Phenyloxindole”,Tetrahedron Letters, 8: pp. 667-670 (1971).
Burkholder, et al., “The Synthesis of 6-Amino-5-Oxo-7-Phenyl-1, 4-Oxazepines As Conformationally ConstrainedCauche(-) Dipeptide Mimetics”,Biog. Med. Chem. Letter, 2: p. 231 (1993).
Busacca, et al., “Synthesis of Novel Tetrahydrobenzazepinones”,Tetrahedron Letters, 33:2, pp. 165-168 (1992).
Butcher, et al., “Preparation of 3-Amino-1,4-Benzodiazepin-2-Ones Via Direct Azidation with Trisyl Azide”,Tetrahedron Letters, 37:37, pp. 6685-6688 (1996).
Chartier-Harlin, et al., “Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-Amyloid precursor protein gene.”,Nature. 353:31, pp. 844-846 (1991).
Citron, et al., “Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-amyloid protein production.”,Nature360:672-674 (1992).
Clark, et al., “Effects of RemoteN(ters-Butoxycarbonyl) Groups on Heteroatom Directed Lithiation at Benzylic Positions”,Tetrahedron, 49:7, pp. 1351-1356 (1993).
Colombo, et al., “Synthesis of 7,58-Fused Bicyclic Lactams by Steroselective Radical Cyclization”,Tetrahedron Letters, 35:23, pp. 4031-4034 (1994).
Cornille, et al., “Electrochemical Cyclication of Dipeptides Toward Novel Cicyclic, Reverse-Turn Peptidomimetics”,J. Am. Chem. Soc., 117: pp. 909-917 (1995).
Crombie, et al., “Transamidation Reactions of β-Lactams”,Tetrahedron Letters, 27:42, pp. 5151-5154 (1986).
Curran, et al., “A Short synthesis of Bicyclic Dipeptides Corresponding to Xxx-L-Pro and Xxx-D-Pro Having ConstrainedCis-Proline Amides”,Tetrahedron Letters, 36, pp. 191-194 (1995).
Das, et al, “Dual Metalloprotease Inhibitors IV”,Biorg. Med. Chem. Lett., 4:18, pp. 2193-2198 (1994).
Desai, et al., “Polymer Bound EDC (P-EDC): A convenient Reagent for Formation of An Amide”,Tetrahedron Letters, 34:48, pp. 7685-7688 (1993).
Dickerman, et al., “Studies in Piperdidone Chemistry”,J. Org. Chem., 14, p. 530-536 (1949).
Dickerman, et al., “The Schmidt6 Reaction with 2,2,6-Trimethyl-And 1,3-Dimethyl-4-Piperidones”,J. Org, Chem., 20: p. 206-209 (1955).
Dickerman, et al., “The Schmidt Reaction with 3-Ethoxycarbonyl-4-P Peripdones and the synt
Audia James A.
Mabry Thomas E.
Neitz R. Jeffrey
Nissen Jeffrey S.
Tung Jay S.
Athena Neurosciences, Inc.
Eli Lilly and Company
Kifle Bruck
Titus Robert D.
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