Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-10-16
2007-10-16
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S365000, C514S385000, C514S396000, C514S403000, C548S316400, C548S186000, C548S152000, C548S128000
Reexamination Certificate
active
10501636
ABSTRACT:
Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.
REFERENCES:
patent: 5444042 (1995-08-01), Bartus et al.
patent: 5501969 (1996-03-01), Hastings et al.
patent: 5514694 (1996-05-01), Powers et al.
patent: 5610297 (1997-03-01), Powers
patent: 5650508 (1997-07-01), Powers
patent: 5670479 (1997-09-01), Abelman et al.
patent: 5763576 (1998-06-01), Powers
patent: 5861298 (1999-01-01), Adams et al.
patent: 5948777 (1999-09-01), Bender et al.
patent: 5948886 (1999-09-01), Peet et al.
patent: 6143931 (2000-11-01), Baldino et al.
patent: 6235929 (2001-05-01), Powers
patent: 6291505 (2001-09-01), Huebner et al.
patent: 6436925 (2002-08-01), Lubisch et al.
patent: 6448254 (2002-09-01), Lubisch et al.
patent: 2005/0043368 (2005-02-01), Deaton et al.
patent: 520 427 (1992-12-01), None
patent: 525 420 (1993-02-01), None
patent: 535 928 (1993-04-01), None
patent: 603 873 (1994-06-01), None
patent: 611 756 (1994-08-01), None
patent: 812 916 (1997-12-01), None
patent: 1 008 592 (2000-06-01), None
patent: 200281640 (1990-11-01), None
patent: 06192199 (1994-07-01), None
patent: 11263783 (1994-07-01), None
patent: 07115985 (1995-05-01), None
patent: 11228526 (1999-08-01), None
patent: 11246436 (1999-09-01), None
patent: 2001011037 (2001-01-01), None
patent: 92/11850 (1992-07-01), None
patent: 92/12140 (1992-07-01), None
patent: 93/24634 (1993-12-01), None
patent: 94/00095 (1994-01-01), None
patent: 94/08941 (1994-04-01), None
patent: 94/21673 (1994-09-01), None
patent: 95/00535 (1995-01-01), None
patent: 96/10014 (1996-04-01), None
patent: 96/16079 (1996-05-01), None
patent: 96/32408 (1996-10-01), None
patent: 96/40647 (1996-12-01), None
patent: 97/16177 (1997-05-01), None
patent: 97/16433 (1997-05-01), None
patent: 97/47642 (1997-12-01), None
patent: 97/49668 (1997-12-01), None
patent: 98/05336 (1998-02-01), None
patent: 98/08802 (1998-03-01), None
patent: 98/46559 (1998-10-01), None
patent: 98/48190 (1998-10-01), None
patent: 9846582 (1998-10-01), None
patent: 98/48799 (1998-11-01), None
patent: 98/50342 (1998-11-01), None
patent: 98/50534 (1998-11-01), None
patent: 99/11637 (1999-03-01), None
patent: 99/11640 (1999-03-01), None
patent: 99/17775 (1999-04-01), None
patent: 99/17778 (1999-04-01), None
patent: 99/17790 (1999-04-01), None
patent: 99/24460 (1999-05-01), None
patent: 99/37666 (1999-07-01), None
patent: 99/53039 (1999-10-01), None
patent: 99/54305 (1999-10-01), None
patent: 99/54310 (1999-10-01), None
patent: 99/54317 (1999-10-01), None
patent: 99/54320 (1999-10-01), None
patent: 99/59526 (1999-11-01), None
patent: 99/59570 (1999-11-01), None
patent: 99/61423 (1999-12-01), None
patent: 99/64399 (1999-12-01), None
patent: 99/66925 (1999-12-01), None
patent: 00/01666 (2000-01-01), None
patent: 00/16767 (2000-03-01), None
patent: 00/18358 (2000-04-01), None
patent: 00/18725 (2000-04-01), None
patent: 00/24704 (2000-05-01), None
patent: 00/29408 (2000-05-01), None
patent: 00/51998 (2000-09-01), None
patent: 00/54769 (2000-09-01), None
patent: 00/55124 (2000-09-01), None
patent: 00/55144 (2000-09-01), None
patent: 00/58296 (2000-10-01), None
patent: 00/59881 (2000-10-01), None
patent: 00/78794 (2000-12-01), None
patent: 01/09169 (2001-02-01), None
Tezuka et al., “Molecular Cloning of a Possible Cystein Proteinase Predominantly Expressed in Osteoclasts,”J. Biol. Chem., 1994, vol. 269, pp. 1106-1109.
Inaoka et al., “Molecular Cloning of Human cDNA for Cathepsin K: Novel Cysteine Proteinase Predominately Expressed in Bone,”Biochem. Biophys. Res. Commun., 1995, vol. 206, p. 89.
Shi, et al., “Molecular cloning of human cathepsin I, a novel endoproteinase asn homologue of rabbit OC2,”FEBS Letters, 1995, vol. 357, p. 129.
Lalonde, J.M. et al., “Use a Papain as a Model for the Structure-Based Design of Cathepsin K Inhibitors: Crystal Structures of Two Papain-Inhibitor Complexes Demonstrate Binding to S-Subsites,”Journal of Medicinal Chemistry, vol. 41, 1998, pp. 4567-4576.
Catalano John George
Deaton David Norman
Miller Aaron Bayne
Tavares Francis Xavier
Anderson Rebecca
Coulter Kathryn L.
Lemanowicz John L.
Shiao Rei-tsang
SmithKline Beecham Corporation
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