Cycloalkyl-hydroxyl compounds and compositions for...

Details Cycloalkyl-hydroxyl compounds and compositions for... Cycloalkyl-hydroxyl compounds and compositions for...

2008-07-29

2008-07-29

Solola, Taofiq A. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S323000, C514S378000, C546S114000, C548S243000, C549S323000

Reexamination Certificate

active

07405226

ABSTRACT:
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

REFERENCES:
patent: 3152148 (1964-10-01), Easterly et al.
patent: 3441605 (1969-04-01), Blake et al.
patent: 3773946 (1973-11-01), Creger
patent: 3930024 (1975-12-01), Creger
patent: 4287200 (1981-09-01), Kawamatsu et al.
patent: 4584321 (1986-04-01), Manghisi et al.
patent: 4613593 (1986-09-01), Yamatsu et al.
patent: 4634719 (1987-01-01), Takaishi et al.
patent: 4689344 (1987-08-01), Bar-Tana
patent: 4711896 (1987-12-01), Bar-Tana et al.
patent: 4714762 (1987-12-01), Hoefle et al.
patent: 5166174 (1992-11-01), Ueno et al.
patent: 5225439 (1993-07-01), Ueno et al.
patent: 5284858 (1994-02-01), Ueno et al.
patent: 5380709 (1995-01-01), Ueno et al.
patent: 5428062 (1995-06-01), Ueno et al.
patent: 5502198 (1996-03-01), Picard et al.
patent: 5504073 (1996-04-01), Homan
patent: 5578639 (1996-11-01), Homan
patent: 5633287 (1997-05-01), Lee et al.
patent: 5648387 (1997-07-01), Bisgaier et al.
patent: 5750569 (1998-05-01), Bisgaier et al.
patent: 5756344 (1998-05-01), Onda et al.
patent: 5756544 (1998-05-01), Gregor et al.
patent: 5783600 (1998-07-01), Bisgaier et al.
patent: 5834596 (1998-11-01), Ageland et al.
patent: 5886034 (1999-03-01), Ueno et al.
patent: 5968963 (1999-10-01), Homan
patent: 5981595 (1999-11-01), Picard et al.
patent: 6004925 (1999-12-01), Dasseux et al.
patent: 6017905 (2000-01-01), Roark et al.
patent: 6037323 (2000-03-01), Dasseux
patent: 6093719 (2000-07-01), Bocan
patent: 6093744 (2000-07-01), Lee et al.
patent: 6124309 (2000-09-01), Bocan
patent: 6143755 (2000-11-01), Bocan
patent: 6459003 (2002-10-01), Dasseux et al.
patent: 6646170 (2003-11-01), Dasseux et al.
patent: 6673780 (2004-01-01), Dasseux et al.
patent: 6699910 (2004-03-01), Dasseux et al.
patent: 6703422 (2004-03-01), Dasseux et al.
patent: 6713507 (2004-03-01), Dasseux et al.
patent: 2005/0214887 (2003-12-01), Dasseux et al.
patent: 2005/0043278 (2005-02-01), Dasseux et al.
patent: 0 284 108 (1993-08-01), None
patent: 1 545 224 (1968-11-01), None
patent: 1196594 (1970-07-01), None
patent: 1196595 (1970-07-01), None
patent: 1196596 (1970-07-01), None
patent: 1196597 (1970-07-01), None
patent: 1196598 (1970-07-01), None
patent: WO 96/30328 (1996-10-01), None
patent: WO 98/30530 (1998-07-01), None
patent: WO 99/00116 (1999-01-01), None
Gutman et al., J. of the Chem. Soc. (1951), vol. 4(20), pp. 2064-2067.
Bicking, et al., “11,12-Secoprostaglandins. 1. Acylhydroxyalkanoic acids and related compounds”, J. Med. Chem., 1977. pp. 35-43, vol. 20.
Nagano H. et al., “Stereoselectivity in the formation and radical reduction of cyclic bromoacetals, key intermediates for the sythesis of delta-hydroxy-and epsilon-hydroxy-alpha-methylearboxylic acid esters”, Tetrahedron Letters, 2003, pp. 6867-6870, vol. 44, No. 36.
Bobrova, et al., abstract, J. Org. Chem, 1983, pp. 259-261, vol. 19.
Narasaka, et al., abstract, Bull. Chem. Soc, 1987, pp. 1457-1464, vol. 60, No. 4.
Rieke, et al., abstract, J. Org. Chem, 1996, pp. 2726-2730, vol. 61, No. 8.
Pechmann, abstract, Chem. Ber., 1904, p. 3819, vol. 37.
Lardelli, et al., abstract, Recl. Trav. Chim., 1967, pp. 481-503, vol. 86.
Crisan, abstract, Ann. Chim., 1956, pp. 436-459, vol. 13, No. 1.
Blatt, et al., The reducing action of the Grignard reagent and the synthesis of tertiary aliphatic carbinols, J. Org. Chem., 1932, pp. 1495-1499, vol. 54.
Brown, et al., “Hydroboration. 67. Cyclic hydroboration of acyclic alpha, omega-dienes with 9-Borabicyclo ′3.3.1 !nonane/borane-dimethyl sulfide”, J. Org. Chem., pp. 1072-1078, vol. 49, No. 6, 1984.
Weber, et al., abstract, J. Med. Chem., 1992, pp. 3755-3773, vol. 35, No. 21.
Yamamoto, “Asymmetric synthesis of 5-and 6-membered lactones from cyclic substrates bearing a c2-chiral auziliary”, J. Org. Chem., 1991, pp. 1112-1119, vol. 35, No. 21.
Ooit, et al., abstract, Angewandte Chemie., 2001, vol. 40, No. 19.
English, J. Am. Chem. Soc., 1941, p. 942, vol. 63.
Gleiter, et al., Sythesis of 5,510,10-tetramethyl-1-oxacyclotridecane-6,7,8,9-tetrone-on the mechanism of the Rubottom reaction, 1995, (9), pp. 1655-1661.
Gleiter, et al., Synthesis and properties of 4,4,9,9-tetramethyl-1-oxa-cycloundecane-5,6,7,8-tetrone and 9-tetramethyl-1-oxa-cyclotridecane-6,7,8,9-tetrone, 1996, 2(3), pp. 271-277.
Momenteau, et al., abstract, J. Chem Soc. Perkin Trans. 1985, pp. 221-232.
Silverman, The Organic Chemistry of Drug Design and Drug Interaction, 1992, pp. 15-22.
Bohme, V. and Lener, W., 1955, Annalen der Chemie, 595;169-178 (English language abstract).
Xu et al., 1989, “The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells”, Oncogene 4: 807-812.
Ackerly, et al., 1995, “A novel approach to dual-acting thomboxane receptor antagonist/synthase inhibitors based on the link of 1.3-dioxane-thrombaxane receptor antagonists and -thromboxane syntase inhibitors”, J. Med. Chem. 38:1608-1628.
Acton et al., 1996, “Identification of scavenger receptor SR-BI as a high density lipoprotein receptor”, Science. 271(5248):518-20.
Ahrens et al., 1967, “A direct method for preparing pridoxal and 4-pyridoxic acid (1)”, J. Heterocycl. Chem. 4:625-26.
Alexander, K. et al., 1948, “4,4′-Dichiorodibutyl either and its derivatives from tetrahydrofuran”, J. Am. Chem. Soc. 70:1838-42.
Badimon et al., 1992, “Role of High density lipoproteins in the regression of atherosclerosis”, Circulation 86 (Suppl):11186-94.
Bailey, et al., 1990, “Convenient general method for the preparation ofprimary alkeyltithiums by lithium-iodine exchange”, J. Org. Chem. 55:5404-06.
Barrans et al., 1996, “Pre-beta HDL; structure and metabolism”, Biochim. Biophys. Acta. 1300(2):73-85.
Becker et al., 1982, “Intramolecular photoaddition of terminal allenes to conjugated cyclohexenones”, J. Org. Chem. 47:3297-3310.
Bernady et al., 1979, “Prostagiandins and congeners. 20..sup.1,2 Synthesis of progstagiandins via conjugate addition of lithiummm trans-1-alkenyltrialkylelanate reagents. A novel reagent for conjugate 1,4-additions”, J. Org. Chem. 44:1438-47.
Bhanot et al., 1977, “Synthetic Studies on Terpenoids.5.Syntheses of .gamma.-and delta.-Lactones from. beta.-(2,7-Dimethyl-1,2-dihydroxycycloheptyl)propionic Acid”, J. Org. Chem. 42:1623-1627.
Bisgaier et al., 1998, “A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activator receptor”, J Lipid Res. 39(1):17-30.
Bigaier et al., 1997, “Attenuation of plasma low density lipopprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice of low density lipoprotein receptors”, J Lipid Res 38 (12):2502-2515.
Bongini et al., 1979 “A simple and practical method for tetrahydropyranylation of alcohols and phanos”, Synthesis 618-620.
Brown et al., 1965, “Selective reductions. VII. Reaction of lithium trimethoxyluminohydr

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