Cycloalkyl alkanoic acids as integrin receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S312000, C546S194000, C546S318000

Reexamination Certificate

active

06900232

ABSTRACT:
The present invention relates to a class of compounds represented by the Formula IWherein A1is a pyridinyl of the formulaoptionally substituted by one or more Rkselected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3and/or αvβ5integrin.

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