Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-11-20
2007-11-20
Tsang, Cecilia J. (Department: 1609)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S090000, C548S438000
Reexamination Certificate
active
11355452
ABSTRACT:
The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1Areceptors and modulating serotonin levels.
REFERENCES:
patent: 2695294 (1954-11-01), Swain
patent: 3769298 (1973-10-01), McManus et al.
patent: 3868387 (1975-02-01), Berger et al.
patent: 4122202 (1978-10-01), Fauran et al.
patent: 4473586 (1984-09-01), DeBernardis et al.
patent: 4618614 (1986-10-01), Hausberg et al.
patent: 4618683 (1986-10-01), DeBernardis et al.
patent: 5049654 (1991-09-01), Morita et al.
patent: 5194437 (1993-03-01), Peglion et al.
patent: 5296484 (1994-03-01), Coghlan et al.
patent: 5324743 (1994-06-01), Dillard et al.
patent: 5439909 (1995-08-01), Guillaumet et al.
patent: 5550125 (1996-08-01), George et al.
patent: 5607961 (1997-03-01), Cipollina et al.
patent: 5723484 (1998-03-01), Lavielle et al.
patent: 5750556 (1998-05-01), Mewshaw et al.
patent: 5814653 (1998-09-01), Flaugh et al.
patent: 5830911 (1998-11-01), Failli et al.
patent: 5935992 (1999-08-01), Flaugh et al.
patent: 6063810 (2000-05-01), Philippo et al.
patent: 6071860 (2000-06-01), Giencke et al.
patent: 6221879 (2001-04-01), Marabout et al.
patent: 6303603 (2001-10-01), Patoiseau et al.
patent: 6432956 (2002-08-01), Dement et al.
patent: 6555559 (2003-04-01), Wakita et al.
patent: 6599915 (2003-07-01), Tran et al.
patent: 6693197 (2004-02-01), Chan et al.
patent: 6747024 (2004-06-01), Auvin et al.
patent: 6762176 (2004-07-01), Chabrier de Lassauniere et al.
patent: 6919360 (2005-07-01), Scherling et al.
patent: 7045629 (2006-05-01), Bokel et al.
patent: 2002/0016359 (2002-02-01), Hellberg et al.
patent: 2002/0177616 (2002-11-01), Fahrig et al.
patent: 2003/0045537 (2003-03-01), Lee et al.
patent: 2003/0073839 (2003-04-01), Ladouceur et al.
patent: 2003/0134870 (2003-07-01), Stack et al.
patent: 2003/0225088 (2003-12-01), Sikorski et al.
patent: 2004/0077652 (2004-04-01), Gross et al.
patent: 924305 (1973-04-01), None
patent: 4419973 (1995-12-01), None
patent: 196 48 384 (1998-05-01), None
patent: 19754573 (1999-06-01), None
patent: 0 004 358 (1982-01-01), None
patent: 0 054 304 (1984-08-01), None
patent: 0 038 564 (1984-09-01), None
patent: 0 323 807 (1989-07-01), None
patent: 0 378 518 (1990-07-01), None
patent: 0 236 930 (1990-10-01), None
patent: 0 492 021 (1992-07-01), None
patent: 0 518 436 (1992-12-01), None
patent: 0 325 963 (1993-09-01), None
patent: 0 558 245 (1993-09-01), None
patent: 0 345 747 (1996-06-01), None
patent: 0 905 136 (1999-03-01), None
patent: 0 884 049 (2002-09-01), None
patent: 1 375 503 (2004-01-01), None
patent: 1 424 337 (2004-06-01), None
patent: 2729141 (1996-07-01), None
patent: 1 005 028 (1965-09-01), None
patent: 1 249 261 (1971-10-01), None
patent: 2 174 705 (1986-11-01), None
patent: 58219114 (1983-12-01), None
patent: 1146876 (1989-06-01), None
patent: 11189536 (1999-07-01), None
patent: 2003212872 (2003-07-01), None
patent: 2003335669 (2003-11-01), None
patent: 2004059538 (2004-02-01), None
patent: 91/13872 (1991-09-01), None
patent: 92/15579 (1992-09-01), None
patent: 92/21671 (1992-12-01), None
patent: 94/14805 (1994-07-01), None
patent: 94/22846 (1994-10-01), None
patent: 96/38441 (1996-12-01), None
patent: 96/39145 (1996-12-01), None
patent: 97/15308 (1997-05-01), None
patent: 97/17343 (1997-05-01), None
patent: 97/23485 (1997-07-01), None
patent: 97/35852 (1997-10-01), None
patent: 97/47601 (1997-12-01), None
patent: 98/40386 (1998-09-01), None
patent: 99/29687 (1999-06-01), None
patent: 99/32476 (1999-07-01), None
patent: 99/62902 (1999-12-01), None
patent: 99/64420 (1999-12-01), None
patent: 00/20423 (2000-04-01), None
patent: 00/35432 (2000-06-01), None
patent: 00/58301 (2000-10-01), None
patent: 00/75136 (2000-12-01), None
patent: 01/10433 (2001-02-01), None
patent: 01/41750 (2001-06-01), None
patent: 01/72741 (2001-10-01), None
patent: 02/44152 (2002-06-01), None
patent: 02/49993 (2002-06-01), None
patent: 02/55012 (2002-07-01), None
patent: 02/85891 (2002-10-01), None
patent: 02/85912 (2002-10-01), None
patent: 02/088133 (2002-11-01), None
patent: 02/088134 (2002-11-01), None
patent: 02/088135 (2002-11-01), None
patent: 02/088136 (2002-11-01), None
patent: 02/088141 (2002-11-01), None
patent: 02/088142 (2002-11-01), None
patent: 02/092602 (2002-11-01), None
patent: 02/008420 (2003-01-01), None
patent: 03/008419 (2003-01-01), None
patent: 03/013511 (2003-02-01), None
patent: 03/013705 (2003-02-01), None
patent: 03/022269 (2003-03-01), None
patent: 03/024960 (2003-03-01), None
patent: 03/029238 (2003-04-01), None
patent: 03/029239 (2003-04-01), None
patent: 03/030901 (2003-04-01), None
patent: 03/031429 (2003-04-01), None
patent: 03/055890 (2003-07-01), None
patent: 03/068253 (2003-08-01), None
patent: 03/104216 (2003-12-01), None
patent: 2004/016601 (2004-02-01), None
patent: 2004/024732 (2004-03-01), None
patent: 2004/024734 (2004-03-01), None
U.S. Appl. No. 10/898,866, filed Jun. 2004, Hatzenbuhler et al.
Hegedus et. al. J. Am. Chem. Soc. 1978, 100, 5800-5807.
Campbell et. al. Chemical Reviews 1947, 40, 359-380.
Robinson, et. al. Chemical Reviews 1963, 63, 373-401.
Amundsen, L.H. et. al. J. Am. Chem. Soc, 1951, 73, 242-244.
Database Beilstein. Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002402724 Database accession No. BRN:5266967 abstract & Tetrahedron, vol. 41, No. 12, 1985, pp. 2557-2566.
Database Beilstein. Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002402725 Database accession No. BRN:6333133 abstract & Naunyn-Schmiedeberg's Arch. Pharmacol., vol. 355, No. 4, 1997, pp. 475-482.
Database Beilstein. Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002402726 Database accession No. BRN:151106 abstract & J. Indian Chem. Soc., vol. 34, 1957, pp. 299-304.
Database Beilstein. Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002402727 Database accession No. BRN:415101 abstract & Justus Liebigs Ann. Chem. vol. 709, 1967, pp. 135-150.
Database Beilstein. Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002402728 Database accession No. BRN:9274684 abstract & J. Med. Chem., vol. 45, No. 18, 2002, pp. 3509-3523.
Database Beilstein. Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002402729 Database accession No. BRN:165230 abstract & J. Indian. Chem. Soc., vol. 34, 1957, pp. 299-304.
Database Beilstein. Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002402730 Database accession No. BRN:189711 abstract & Bull. Soc. Chim. Fr., 1952, pp. 336-340.
Glennon, R. A. et al., “2-Substituted Tryptamines: Agents with Selectivity for 5-HT6Serotonin Receptors,” Journal of Medicinal Chemistry, American Chemical Society, Washinton, US, vol. 43, No. 5, 2000, pp. 1011-1018, XP002201555.
Block, M. H., et al., “Discovery and Optimization of a Series of Carbazole Ureas as NPY5 Antagonists for the Treatment of Obesity,”J. Med. Chem.2002, 45, 3509-3523.
Bundgaard, H. (ed.),Design of Prodrugs, Elsevier (1985), Ch. 1 (pp. 1-92), Ch. 4 (pp. 157-176), Ch. 5 (pp. 177-198), and Ch. 6 (pp. 199-241).
Bundgaard, H. et al., “Glycolamide Esters as Biolabile Prodrugs of Carboxylic Acid Agents: Synthesis, Stability, Bioconversion, and Physicochemical Properties,”J. of Pharmaceutical Sciences, Apr. 1988, 77(4), 285-298.
Bundgaard, H., “Means to enhance penetration; Prodrugs as a means to improve the delivery of peptide drugs,”Advanced Drug Deliver Reviews, 1992, 8, 1-38.
Cheetham, S. C. et al., “[3H]Paroxetine Binding in Rat Frontal Cortex Strongly Correlates With [3H]Paroxetine Binding in Rat Frontal Cortex Strongly Correlates With [3H]5-HT Uptake: Effect of Administration of Various Antidepressant Treatments,”Neuropharmacol., 1993, 32(8), 737-743.
Cheng, Y-C. et al., “Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reacti
Baudy Reinhardt Bernhard
Chan Anita Wai-Yin
Evrard Deborah Ann
Failli Amedeo Arturo
Guinosso Charles J.
O'Dell David K
Tsang Cecilia J.
Woodcock & Washburn LLP
Wyeth
LandOfFree
Cycloalkyfused indole, benzothiophene, benzofuran and idene... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cycloalkyfused indole, benzothiophene, benzofuran and idene..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cycloalkyfused indole, benzothiophene, benzofuran and idene... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3803748