Cycloalkltriols containing cyclic substituents, processes and in

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514262, 544239, 544241, 544262, 544264, 544265, 544276, 544277, 544314, 544317, 544318, 546118, 546301, 5482668, 5482686, 5483044, 5483311, 548473, 548545, 548548, A61K 3152, C07D47330, C07D47334, C07D47318

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056312598

ABSTRACT:
Cycloalkyltriols containing heterocyclic substituents, in particular cyclopentyl- and cyclohexyltriols containing heterocyclic substituents
Compounds of the formulae I and II ##STR1## in which the substituents A, R.sup.1, R.sup.2 and R.sup.3 and n have the meanings given, have an antiviral and antiparasitic action.

REFERENCES:
Cecil Textbook of Medicine, 19th Edition p. 1844 (1992).
Patil, J Med Chem 35, 3374 (1992).
Kizilisik, Transplantation Proc. 25, 2282 (1993).
Edman, Nature 334, 519 (1988).
Barry M. Trost, Gee-Hong Kuo & Torre Benneche: "A Transition-Metal-Controlled Synthesis of (.+-.)-Aristeromycin and (.+-.)-2',3'-diepi-Aristeromycin. An Unusual Directive Effect in Hydroxylations," J. Am. Chem. Soc., vol. 110, pp. 621-622 (1988).
Sharadbala D. Patil & Stewart W. Schneller: "(.+-.)-5'-Nor Ribofuranoside Carbocyclic Guanosine"; Journal of Heterocyclic Chemistry, vol. 28, No. 3, pp. 823-825 (1991).
Chemical Abstracts; American Chemical Society, vol. 109, N. 11, p. 701 (Sep. 12, 1988) 92898u.
Chemical Abstracts: American Chemical Society, vol. 112, N. 21, p. 263, (May 21, 1990) 193759s.
Chemical Abstracts: American Chemical Society, vol. 99, N. 5, p. 490, (Aug. 1, 1983) 38081j.
Chemical Abstracts: American Chemical Society, vol. 83, No. 25, p. 352, (Dec. 22, 1975). 205806c.
Chemical Abstracts: American Chemical Society, vol. 86, No. 5, p. 329, (Jan. 31, 1977) 29396v.
Chemical Abstracts: American Chemical Society, vol. 96, No. 13, p. 657, (Mar. 29, 1982) 10370o.
Diane M. Coe, et al., "Synthesis of Some Mimics of Nucleoside Triphosphates"; J. Chem. Soc. Chem. Commun., pp. 312-314 (Mar. 1, 1991).
Micheal R. Peel, Daniel D. Sternbach & M. Ross Johnson: "A Short, Enantioselective Synthesis of the Carbocyclic Nucleoside Carbovir"; The Journal of Organic Chemistry; The American Chemical Society, vol. 56, No. 16, pp. 4490-4493 (1991).
Diane M. Coe, David C. Orr, Stanley M. Roberts & Richard Storerside: "Preparation of Nucleotide Mimics with Potent Inhibitory Activity Against HIV Reverse Transcriptase"; Journal of the Chemical Society, Perkin Transactions 1, No. 12, pp. 3378-3379 (Dec. 1991).
Merck Index, 11th Edition, 1989, p. 1017.
Hawley's Condensed Chemical Dictionary, 11th Edition (1990) p. 21.
Resolution of Aristeromycin Enantiomers, J. Med. Chem., vol. 28, pp. 1385-1386, 1985.
De Clercq, "Antiviral and Antimetabolic Activities of Neplanocins", Anti-microbial Agents and Chemotherapy, vol. 28, No. 1, pp. 84-89, Jul. 1985.
Hasobe et al., "Elucidation of the Mechanism by which Homocysteine Potentiates the Anti-Vaccinia Virus Effects of the S-Adenosylhomocysteine Hydrolase Inhibitor 9-(trans-2', trans-3'-Dihydroxycyclopent-4'-enyl)-adenine", Molecular Pharmacology, vol. 36, pp. 490-496, Jun. 1989.
Trost et al. "A Transition-Metal-Controlled Synthesis of (.+-.)-Aristeromycin and (.+-.)-2', 3'-diepi-Aristeromycin: An Unusual Directive Effect in Hydroxylations", J. Am. Chem. Soc., vol. 110, pp. 621-622, 1988.
Marquez et al., Carbocyclic Nucleosides, Medicinal Research Reviews, vol. 6 No. 1, pp. 1-40, 1986.

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