Cycloalkenyl analogues of prostaglandins E

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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260514D, 260586R, 260611B, 260617R, 260648R, 424305, 424317, C07C17700

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active

040668347

ABSTRACT:
Analogues of prostaglandins A, E, and F in which the C.sub.13 -C.sub.20 chain of the natural prostaglandins is replaced by a cycloalkenyl or a hydroxycycloalkenyl moiety such that vinylene radical and the hydroxyl group of the ring respectively retain their natural sequential positions at C.sub.13 -C.sub.14 and C.sub.15, inhibit aggregation of platelets in vitro and exhibit useful cardiovascular activity in vivo.

REFERENCES:
Arndt et al., Prostaglandins 9, 521(1975).
Crossley, Chem. and Ind. pp. 335-336 (1976).

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