Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1975-10-20
1978-01-03
Gerstl, Robert
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
260514D, 260586R, 260611B, 260617R, 260648R, 424305, 424317, C07C17700
Patent
active
040668347
ABSTRACT:
Analogues of prostaglandins A, E, and F in which the C.sub.13 -C.sub.20 chain of the natural prostaglandins is replaced by a cycloalkenyl or a hydroxycycloalkenyl moiety such that vinylene radical and the hydroxyl group of the ring respectively retain their natural sequential positions at C.sub.13 -C.sub.14 and C.sub.15, inhibit aggregation of platelets in vitro and exhibit useful cardiovascular activity in vivo.
REFERENCES:
Arndt et al., Prostaglandins 9, 521(1975).
Crossley, Chem. and Ind. pp. 335-336 (1976).
Arndt Henry Clifford
Biddlecom William Gerard
Peruzzotti George Peter
Sih Charles John
Woessner Warren Dexter
Gerstl Robert
Miles Laboratories Inc.
Schwalbach Joseph C.
Winchell Richard W.
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