Cycloalkanol esters of dihydrolysergic acid useful as 5Ht.sub.2

Details Cycloalkanol esters of dihydrolysergic acid useful as 5Ht.sub.2 Cycloalkanol esters of dihydrolysergic acid useful as 5Ht.sub.2

1985-10-01

1987-07-28

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 67, 546 68, 546 69, A61K 3148, C07D45704

Patent

active

046832360

ABSTRACT:
Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acids, useful as 5HT.sub.2 receptor antagonists.

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Cohen et al., J.P.E.T., 227, 327 (1983 (Cohen I).
Cohen et al., ibid, 232, 770 (1984) (Cohen II).
Lemberger et al., Life Sci., 35, 71 (1984).
Cohen et al., Drug Dev. Res., 5, 313 (1985) (Cohen IV).
Hingten et al., Abstract 37.4, Soc. for Neurosci. (13th Annual Meeting, Nov. 1983).

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