Cycloalkano-pyridines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514261, 514305, 514311, 514256, 514334, 514335, 514336, 514337, 514338, 514339, 514340, 514341, 514342, 544245, 544333, 546139, 546148, 546152, 546176, 546255, 5462701, 5462717, 5462734, 5462797, 5462817, A61K 31438, A61K 3147, C07D21500, C07D21700

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060691484

ABSTRACT:
The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The, cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hyperlipoproteinaemia and arteriosclerosis.

REFERENCES:
patent: 4814346 (1989-03-01), Albert et al.
patent: 5006530 (1991-04-01), Angerbauer et al.
patent: 5169857 (1992-12-01), Angerbauer et al.
Khim. Geterotsikl. Soedin. (1967) (6), pp. 1118-1120.
Chemical Abstracts, vol. 93, No. 19, Nov. 10, 1980, Abstract No. 186126, Competing reactions of .beta.-dicarbonyl and .beta.-aminovinylcarbonyl compounds with aldehydes in the synthesis of hexahydroquinolines.

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