Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodil

Details Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodil Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodil

1987-01-27

1988-03-29

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548369, A61K 31415, C07D23154, C07D23156

Patent

active

047344296

ABSTRACT:
The present invention is directed to a group of methylated tetrahydro cyclohepta[1,2-c:4,3-c']dipyrazoles and benzo[1,2-c:4,3-c']dipyrazoles useful as bronchodilators. The compounds are prepared by the reaction of an appropriate hydrazine with an appropriate 1,3-diketone or with a compound that is chemically equivalent to a 1,3-diketone.

REFERENCES:
patent: 3404157 (1968-10-01), McEvoy et al.
patent: 4515948 (1985-05-01), Kompis et al.
C. Ruchardt, V. Hassmann, Liebigs Ann. Chem., 6:908-27 (1980).
Heterocyclic Compounds, vol. 5, R. C. Elderfield, ed., John Wiley & Sons, Inc., New York, N.Y., 1957, p. 173.
Beilstein, 4th ed., vol. 26, 579, J. U. Nef, Liebigs Annalen Der Chemie, 258:261 (1890).
V. Vesely, A. Medvedeva, Collection Czechoslav Chem. Commun., 9:176-84 (1937).

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