Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1979-05-15
1985-09-17
Garner, Vivian
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
260455B, 260456A, 260463, 260465B, 260544N, 514929, 560 39, 560 86, 560138, 560142, 562444, 564302, 564304, 564364, A61K 31135, C07C 9123, C07C 9134, C07C 9710
Patent
active
045421595
ABSTRACT:
There are prepared compounds of the formula: ##STR1## wherein X is the group >C.dbd.O or >CH(OH), Y is the group ##STR2## R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl, R.sub.3 is hydrogen or a hydroxy group and R.sub.1 is the adamantyl group or a saturated or single unsaturated C.sub.3 to C.sub.16 cycloalkyl group where the C.sub.3 to C.sub.16 cycloalkyl group can be substituted by a C.sub.1 -C.sub.4 alkyl group or a halogen atom and their salts. The compounds are useful in dilating the peripheral blood vessels and in lowering blood pressure.
REFERENCES:
patent: 3395143 (1968-07-01), Thiele et al.
patent: 3646145 (1972-02-01), Thiele
patent: 3829469 (1974-08-01), Thiele et al.
patent: 4131686 (1978-12-01), Ikezaki et al.
Kalm J. Org. Chem. vol. 25, pp. 1929-1937.
Pfanz, Liebigs Annalen, vol. 614, pp. 149-158.
Royals, J. Org. Chem., vol. 15, pp. 1147-1154.
Engel Jurgen
Kleemann Axel
Posselt Klaus
Stroman Fritz
Thiemer Klaus
Degussa Akteinsellschaft
Garner Vivian
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