Cyclized peptides and their use as platelet aggregation inhibito

Details Cyclized peptides and their use as platelet aggregation inhibito Cyclized peptides and their use as platelet aggregation inhibito

1989-07-17

1995-01-24

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

053843096

ABSTRACT:
The invention in its broad aspects relates to peptide derivatives which are useful as inhibitors platelet function mediated by the GP llbllla receptor and for the prevention of thrombus formation. The compounds of this invention are shown by the following Formula I: ##STR1## and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4517686 (1985-05-01), Ruoslahti et al.
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4614517 (1986-09-01), Ruoslahti et al.
patent: 4661111 (1987-04-01), Ruoslahti et al.
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4792525 (1988-12-01), Ruoslahti et al.
patent: 4857508 (1989-08-01), Adams et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 5041380 (1991-08-01), Ruoslathi et al.
Sixma et al., Thrombosis Research, 67:305-311 (1992).
Kloczewiak et al. Biochemistry, 23:1767-1774 (1984).
Gartner, T. K. and Bennett, J. S., J. Biol. Chem., 260:11891-11894 (1985).
Kieffer, N. and Phillips, D. R., Annu. Rev. Cell Biol., 36:329-357 (1990).
Plow et al., Proc. Natl. Acad. Sci. USA, 82: 8057-8061 (1985).
Pytela et al., Proc. Natl. Acad. Aci. USA, 82: 5766-5770 (1985).
Pytela et al., Cell, 40: 191-198 (1985).
Pytela et al., Science, 231: 1559-1562 (1985).
Gardner, et al., Cell, 42:439-448 (1985).
Ruggeri et al., Proc. Natl. Acad. Sci., 83: 5708-5712 (1986).
Spatola, A. F. and Krzysztof, D., Tetrahedron, 44(3): 821-833 (1988).
Gero, T. and spatola, A. F., Biochem Biophys, Res. Comm., 120(3): 840-845 (1984).
Edwards, J. V. and Spatola, A. F., Biochem Biophys. Res. Comm., 136(2: 730-736 (1986).
Spatola, A. F. and Edwards, J. V. Biopolymers, 25: S229-S244 (1986).
Ginsberg et al., J. Biol. Chem., 260: 3931-3936 (1985).
Pierschbacher et al., Proc. Natl. Acad. Sci., 81:5985-5988 (1984).
Pierschbacher et al., Nature, 309:30-33 (1984).
D'Souza et al., J. Biol. Chem., 26: 33943-3951 (1988).
Parise et al., J. Biol. Chem., 262: 12597-12602 (1987).
Toda et al., J. Cell. Biol., 105: 3097-3104 (1987).
Singer et al., J. Cell. Biol., 104: 573-584 (1987).
Lash et al., Develop Biol., 123: 411-420 (1987).
Haskel et al., Thromb, Res., 56: 687-695 (1989).
Ali et al., Peptides Proc. 11th Amer. Peptide Symposium, La Jolla, CA, Marshall & Rivier, eds. (Jul. 9-14, 1989).
Pierschbacher et al., J. Biol. Chem., 262: 17294-298 (1987).
Garsky et al., Pro. Natl. Acad. Sci. USA, 86: 4022-4026 (1989).
Dennis et al., Pro Natl. Acad. Sci. USA, 87: 2471-2475 (1989).
Chao et al., Pro. Natl. Acad. Sci. USA, 86: 8050-8054 (1989).
Shebuski et al., J. Biol. Chem., 264: 21550-21556(1989).
Gan et al., J. Biol. Chem., 263: 19827-19832 (1989).
Huang et al., Biochemistry, 28: 661-666 (1989).
Huang et al., J. Biol. Chem., 262: 16157-1613 (1987).
Joubert, Francois J. & Taljaard, Nico, Biochimica et Biophysica Acta, 579: 228-233 (1979).
Pierschbacher et al., J. Biol. Chem., vol. 282, No. 86, 1987, pp. 17294-17298.

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