Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-01-03
2010-10-26
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S218000, C514S228800, C514S230800, C514S326000, C514S376000, C540S488000, C540S492000, C544S097000, C544S139000, C544S370000, C548S231000
Reexamination Certificate
active
07820646
ABSTRACT:
The present invention relates to new substituted imidazole compounds have the following Formula (I) and to the pharmaceutically acceptable salts, esters, or prodrugs thereof, to compositions of the compounds together with pharmaceutically acceptable carriers, and to uses of the compounds:
REFERENCES:
patent: 4152440 (1979-05-01), Gebert et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4501728 (1985-02-01), Geho et al.
patent: 4837028 (1989-06-01), Allen
patent: 5011472 (1991-04-01), Aebischer et al.
patent: 5023252 (1991-06-01), Hseih
patent: 6172087 (2001-01-01), Steiner et al.
patent: 6271241 (2001-08-01), DeSimone et al.
patent: 6545004 (2003-04-01), Finer et al.
patent: 6562831 (2003-05-01), Finer et al.
patent: 6630479 (2003-10-01), Finer et al.
patent: 7291641 (2007-11-01), Chabrier De Lassauniere et al.
patent: 2004/0132788 (2004-07-01), Chabrier De Lassauniere et al.
patent: 2005/0187277 (2005-08-01), Mjalli
patent: 2005/0215546 (2005-09-01), Hurnaus et al.
patent: 2005/0228002 (2005-10-01), Wang et al.
patent: 2005/0261337 (2005-11-01), Wang et al.
patent: 2006/0009472 (2006-01-01), Wang et al.
patent: 2006/0084687 (2006-04-01), Boyce et al.
patent: 2007/0037853 (2007-02-01), Barsanti et al.
patent: 2008/0200462 (2008-08-01), Xi et al.
patent: 2 157 285 (1985-10-01), None
patent: WO 98/27108 (1998-06-01), None
patent: WO 00/23487 (2000-04-01), None
patent: WO 00/59887 (2000-10-01), None
patent: WO 01/26656 (2001-04-01), None
patent: WO 01/30768 (2001-05-01), None
patent: WO 01/83575 (2001-11-01), None
patent: WO 01/94317 (2001-12-01), None
patent: WO 01/94318 (2001-12-01), None
patent: WO 01/98278 (2001-12-01), None
patent: WO 02/10140 (2002-02-01), None
patent: WO 02/28839 (2002-04-01), None
patent: WO 02/46168 (2002-06-01), None
patent: WO 02/056880 (2002-07-01), None
patent: WO 02/057244 (2002-07-01), None
patent: WO 02/083143 (2002-10-01), None
patent: WO 03/039460 (2003-05-01), None
patent: WO 03/043995 (2003-05-01), None
patent: WO 03/049527 (2003-06-01), None
patent: WO 03/049678 (2003-06-01), None
patent: WO 03/049679 (2003-06-01), None
patent: WO 03/050064 (2003-06-01), None
patent: WO 03/050122 (2003-06-01), None
patent: WO 03/059289 (2003-07-01), None
patent: WO 03/070701 (2003-08-01), None
patent: WO 03/076432 (2003-09-01), None
patent: WO 03/079973 (2003-10-01), None
patent: WO 03/088903 (2003-10-01), None
patent: WO 03/093263 (2003-11-01), None
patent: WO 03/093264 (2003-11-01), None
patent: WO 03/094839 (2003-11-01), None
patent: WO 03/097053 (2003-11-01), None
patent: WO 03/097643 (2003-11-01), None
patent: WO 03/099211 (2003-12-01), None
patent: WO 03/103575 (2003-12-01), None
patent: WO 03/105855 (2003-12-01), None
patent: WO 03/106417 (2003-12-01), None
patent: WO 03/106426 (2003-12-01), None
patent: WO 2004/004652 (2004-01-01), None
patent: WO 2004/006865 (2004-01-01), None
patent: WO 2004/009036 (2004-01-01), None
patent: WO 2004/018058 (2004-03-01), None
patent: WO 2004/024086 (2004-03-01), None
patent: WO 2004/026226 (2004-04-01), None
patent: WO 2004/031174 (2004-04-01), None
patent: WO 2004/041808 (2004-05-01), None
patent: WO 2004/041809 (2004-05-01), None
patent: WO 2004/064741 (2004-08-01), None
patent: WO 2004/071448 (2004-08-01), None
patent: WO 2004/100873 (2004-11-01), None
patent: WO 2004/103282 (2004-12-01), None
patent: WO 2004/113335 (2004-12-01), None
patent: WO 2005/100322 (2005-10-01), None
patent: WO 2005/107762 (2005-11-01), None
patent: WO 2006/002236 (2006-01-01), None
patent: WO 2007/021794 (2007-02-01), None
U.S. Appl. No. 12/242,360, filed Sep. 30, 2008, Wang et al.
Kapoor, et al., “Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5”,J. Cell Biol., 150:975-988 (2000).
Enos, et al., “Mutation of a Gene That Encodes a Kinesin-like Protein Blocks Nuclear Division inA. nidulans”, Cell60:1019-1027, (1990).
Hagan, et al., “Novel potential mitotic motor protein encoded by the fission yeast cut7+gene”,Nature347:563-566, (1990).
Giet, et al., “TheXenopus laevisAurora-related Protein Kinase pEg2 Associates with an Phosphorylates the Kinesin-related Protein X1Eg5*”, J.Biol. Chem.274(21): 15005-15013, (1999).
Mayer, et al., “Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen”,Science286:971-974, (1999).
Debonis, et al., “Interaction of the Mitotic Inhibitor Monastrol with Human Kinesin Eg5+”Biochemistry, 42:338-349, (2003).
IUPAC, Commission on Nomenclature of Organic Chemistry, Organic Chemistry Division, “Rules for the Nomenclature of Organic Chemistry”, Section E: Stereochemistry,Pure&Appl. Chem.45:13-30, (1976).
Kaiser, et al., “All-trans-Retinoic Acid-mediated Growth Inhibition Involves Inhibition of Human Kinesin-related Protein HsEg5*”,J. Biol. Chem.274:18925-18931, (1999).
Shirley, et al., “The Metalation of 1-Methyl-, 1-Benzyl- and 1-Phenylimidazole with n-Butyllithium”,J. Amer. Chem. Soc., 79:4922-4927 (1957).
Whitten, et al., “A One Step Synthesis of 4-Substituted Imidazoles. An Important Observation When N-Alkylating Imidazoles”,J. Heterocyclic Chem,. 25:1845-1847 (1988).
Matthews, et al., “Synthesis and Cardiotonic Activity of Novel Biimidazoles”,J. Med. Chem, 33(1): 317-327 (1990).
Deng, et al., “Synthetic Applications of Azolium Ylides to a Traceless Solid-Phase Synthesis of 2-Substituted Azoles”,Organic Letters, 4(23): 4017-4020 (2002).
Gebert, et al., Untersuchungen zur Struktur-Wirkung-Beziehung neuer Trans-aminatoren mit Imidazol-, Thiazol- und Benzimidazolgeriist**), Liebigs Ann. Chem., 644-654 (1974) (with English abstract).
Blangy, et al., “Phosphorylatin by p34cdc2Regulates Spindle Association of Human Eg5, a Kinesin-Related Motor Essential for Bipolar Spindle Formation In Vivo”, Cell, vol. 83, 1159-1169 (1995).
Prodrug [online], [retrieved on Mar. 11, 2007]. Retrieved from the Internet, URL; http://en.wikipedia.org/wiki/Prodrugs.
RN 154508-94-8, retrieved from CAPLUS on Oct. 3, 2007.
RN 301154-06-3, retrieved from CAPLUS on Oct. 3, 2007.
Haque, et al., “Monastrol, a Prototype Anti-Cancer Drug That Inhibits a Mitotic Kinesin, Induces Rapid Burst of Axonal Outgrowth From Cultured Postmitotic Neurons, Cell Motility and the Cytoskeleton,” Dept. of Neurobiology and Anatomy, Drexel University College of Medicine, Philidelphia, PA., 58:10-16 (2004).
Barsanti Paul A.
Boyce Rustum
Martin Eric
Wang Weibo
Yang Hong
Kathardekar Vinit
Kifle Bruck
Novartis Vaccines and Diagnostics Inc.
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